Genetic clustering algorithms, implemented in programs such as STRUCTURE and
ADMIXTURE, have been used extensively in the characterisation of individuals and populations …

Genetic architecture describes the characteristics of genetic variation that are responsible for
heritable phenotypic variability. It depends on the number of genetic variants affecting a trait…

Replicable genetic association signals have consistently been found through genome-wide
association studies in recent years. The recent dramatic expansion of study sizes improves …

The advent of genome-wide dense variation data provides an opportunity to investigate
ancestry in unprecedented detail, but presents new statistical challenges. We propose a novel …

Fine-scale genetic variation between human populations is interesting as a signature of
historical demographic events and because of its potential for confounding disease studies. We …

High-coverage whole-genome sequence studies have so far focused on a limited number 1
of geographically restricted populations 2 , 3 , 4 , 5 , or been targeted at specific diseases, …

Characterizing genetic influences on DNA methylation (DNAm) provides an opportunity to
understand mechanisms underpinning gene regulation and disease. In the present study, we …

Powerful approaches to inferring recent or current population structure based on nearest
neighbor haplotype “coancestry” have so far been inaccessible to users without high quality …

Large studies use genotype data to discover genetic contributions to complex traits and infer
relationships between those traits. Co-incident geographical variation in genotypes and …

The maritime expansion of Scandinavian populations during the Viking Age (about ad 750–1050)
was a far-flung transformation in world history 1, 2. Here we sequenced the genomes …