The dynamic behaviour of epithelial cell sheets plays a central role during development,
growth, disease and wound healing. These processes occur as a result of cell adhesion, …

It has been suggested that the quality of clinical trials should be assessed by blinded raters
to limit the risk of introducing bias into meta-analyses and systematic reviews, and into the …

The computational detection of pulmonary lobes from CT images is a challenging segmentation
problem with important respiratory health care applications, including surgical planning …

Chaste — Cancer, Heart And Soft Tissue Environment — is an open source C++ library for
the computational simulation of mathematical models developed for physiology and biology. …

Simulation of cardiac electrical activity using the bidomain equations can be a massively
computationally demanding problem. This study provides a comprehensive guide to numerical …

Aims The level of inhibition of the human Ether-à-go-go-related gene (hERG) channel is one
of the earliest preclinical markers used to predict the risk of a compound causing Torsade-…

In this paper we consider the validity and power of some commonly used statistics for assessing
the degree of homogeneity between trials in a meta-analysis. We show, using simulated …

Chaste (‘Cancer, heart and soft-tissue environment’) is a software library and a set of test
suites for computational simulations in the domain of biology. Current functionality has arisen …

Successful adaptation to varying microenvironmental constraints plays a crucial role during
carcinogenesis. We develop a hybrid cellular automation approach to investigate the cell–…

The coordinated behaviour of populations of cells plays a central role in tissue growth and
renewal. Cells react to their microenvironment by modulating processes such as movement, …