… DJ Dilworth, and operating grants from the CIHR to RA Rachubinski and JD Aitchison. T.
Galitski is a recipient of a Burroughs Wellcome Fund Career Award in the Biomedical Sciences. …

Nucleocytoplasmic transport is mediated by the interplay between soluble transport factors
and nucleoporins resident within the nuclear pore complex (NPC). Understanding this …

Muscle-eye-brain disease (MEB) and Walker Warburg Syndrome (WWS) belong to a spectrum
of autosomal recessive diseases characterized by ocular dysgenesis, neuronal migration …

We have dissected specialized assemblies on the Saccharomyces cerevisiae genome that
help define and preserve the boundaries that separate silent and active chromatin. These …

Nuclear pore complexes (NPCs) govern macromolecular transport between the nucleus
and cytoplasm and serve as key positional markers within the nucleus. Several protein …

Organisms orchestrate cellular functions through transcription factor (TF) interactions with their
target genes, although these regulatory relationships are largely unknown in most species…

We must reliably map the interactomes of cellular macromolecular complexes in order to fully
explore and understand biological systems. However, there are no methods to accurately …

Peroxisome proliferation occurs by at least two routes, division of existing peroxisomes and
de novo biogenesis from the endoplasmic reticulum (ER). The proteins and molecular …

Kap123p is a yeast β-karyopherin that imports ribosomal proteins into the nucleus prior to
their assembly into preribosomal particles. Surprisingly, Kap123p is not essential for growth, …

In addition to its role in nucleocytoplasmic transport, the nuclear pore complex (NPC) acts
as a docking site for proteins whose apparent primary cellular functions are unrelated to …