User profiles for D. J. Balick
 | Daniel J. BalickInstructor at Harvard Medical School Verified email at hms.harvard.edu Cited by 1023 |
Distribution of fixed beneficial mutations and the rate of adaptation in asexual populations
When large asexual populations adapt, competition between simultaneously segregating
mutations slows the rate of adaptation and restricts the set of mutations that eventually fix. This …
mutations slows the rate of adaptation and restricts the set of mutations that eventually fix. This …
Estimating the selective effects of heterozygous protein-truncating variants from human exome data
The evolutionary cost of gene loss is a central question in genetics and has been investigated
in model organisms and human cell lines 1, 2, 3. In humans, tolerance of the loss of one or …
in model organisms and human cell lines 1, 2, 3. In humans, tolerance of the loss of one or …
Dynamic mutation–selection balance as an evolutionary attractor
The vast majority of mutations are deleterious and are eliminated by purifying selection. Yet
in finite asexual populations, purifying selection cannot completely prevent the accumulation …
in finite asexual populations, purifying selection cannot completely prevent the accumulation …
[HTML][HTML] Quantification of frequency-dependent genetic architectures in 25 UK Biobank traits reveals action of negative selection
Understanding the role of rare variants is important in elucidating the genetic basis of human
disease. Negative selection can cause rare variants to have larger per-allele effect sizes …
disease. Negative selection can cause rare variants to have larger per-allele effect sizes …
[HTML][HTML] Dominance of deleterious alleles controls the response to a population bottleneck
Population bottlenecks followed by re-expansions have been common throughout history of
many populations. The response of alleles under selection to such demographic …
many populations. The response of alleles under selection to such demographic …
Applicability of the mutation–selection balance model to population genetics of heterozygous protein-truncating variants in humans
The fate of alleles in the human population is believed to be highly affected by the stochastic
force of genetic drift. Estimation of the strength of natural selection in humans generally …
force of genetic drift. Estimation of the strength of natural selection in humans generally …
[PDF][PDF] Overcoming constraints on the detection of recessive selection in human genes from population frequency data
The identification of genes that evolve under recessive natural selection is a long-standing
goal of population genetics research that has important applications to the discovery of genes …
goal of population genetics research that has important applications to the discovery of genes …
Quantification of frequency-dependent genetic architectures and action of negative selection in 25 UK Biobank traits
Understanding the role of rare variants is important in elucidating the genetic basis of human
diseases and complex traits. It is widely believed that negative selection can cause rare …
diseases and complex traits. It is widely believed that negative selection can cause rare …
Response to a population bottleneck can be used to infer recessive selection
Here we present the first genome wide statistical test for recessive selection. This test uses
explicitly non-equilibrium demographic differences between populations to infer the mode of …
explicitly non-equilibrium demographic differences between populations to infer the mode of …
Rare beneficial mutations can halt Muller's ratchet
The vast majority of mutations are deleterious, and are eliminated by purifying selection. Yet
in finite asexual populations, purifying selection cannot completely prevent the …
in finite asexual populations, purifying selection cannot completely prevent the …