User profiles for D. E. Weinberg
 | David WeinbergFreenome Inc. Verified email at freenome.com Cited by 3331 |
RNAi in budding yeast
IA Drinnenberg, DE Weinberg, KT Xie, JP Mower… - Science, 2009 - science.org
RNA interference (RNAi), a gene-silencing pathway triggered by double-stranded RNA, is
conserved in diverse eukaryotic species but has been lost in the model budding yeast …
conserved in diverse eukaryotic species but has been lost in the model budding yeast …
[HTML][HTML] Improved ribosome-footprint and mRNA measurements provide insights into dynamics and regulation of yeast translation
Ribosome-footprint profiling provides genome-wide snapshots of translation, but technical
challenges can confound its analysis. Here, we use improved methods to obtain ribosome-…
challenges can confound its analysis. Here, we use improved methods to obtain ribosome-…
Structure of yeast Argonaute with guide RNA
The RNA-induced silencing complex, comprising Argonaute and guide RNA, mediates RNA
interference. Here we report the 3.2 Å crystal structure of Kluyveromyces polysporus …
interference. Here we report the 3.2 Å crystal structure of Kluyveromyces polysporus …
The helicase Ded1p controls use of near-cognate translation initiation codons in 5′ UTRs
UP Guenther, DE Weinberg, MM Zubradt, FA Tedeschi… - Nature, 2018 - nature.com
The conserved and essential DEAD-box RNA helicase Ded1p from yeast and its mammalian
orthologue DDX3 are critical for the initiation of translation 1 . Mutations in DDX3 are linked …
orthologue DDX3 are critical for the initiation of translation 1 . Mutations in DDX3 are linked …
[HTML][HTML] Perinatal licensing of thermogenesis by IL-33 and ST2
…, Y Sogawa, AM Bertholet, RM Locksley, DE Weinberg… - Cell, 2016 - cell.com
For placental mammals, the transition from the in utero maternal environment to postnatal
life requires the activation of thermogenesis to maintain their core temperature. This is …
life requires the activation of thermogenesis to maintain their core temperature. This is …
CAT-tailing as a fail-safe mechanism for efficient degradation of stalled nascent polypeptides
Ribosome stalling leads to recruitment of the ribosome quality control complex (RQC),
which targets the partially synthesized polypeptide for proteasomal degradation through the …
which targets the partially synthesized polypeptide for proteasomal degradation through the …
The subcellular distribution of an RNA quality control protein, the Ro autoantigen, is regulated by noncoding Y RNA binding
S Sim, DE Weinberg, G Fuchs, K Choi… - Molecular biology of …, 2009 - Am Soc Cell Biol
The Ro autoantigen is a ring-shaped RNA-binding protein that binds misfolded RNAs in nuclei
and is proposed to function in quality control. In the cytoplasm, Ro binds noncoding RNAs…
and is proposed to function in quality control. In the cytoplasm, Ro binds noncoding RNAs…
[HTML][HTML] The inside-out mechanism of Dicers from budding yeasts
The Dicer ribonuclease III (RNase III) enzymes process long double-stranded RNA (dsRNA)
into small interfering RNAs (siRNAs) that direct RNA interference. Here, we describe the …
into small interfering RNAs (siRNAs) that direct RNA interference. Here, we describe the …
In vitro analysis of RQC activities provides insights into the mechanism and function of CAT tailing
10.7554/eLife.27949.001 Ribosomes can stall during translation due to defects in the mRNA
template or translation machinery, leading to the production of incomplete proteins. The …
template or translation machinery, leading to the production of incomplete proteins. The …
Candida albicans Dicer (CaDcr1) is required for efficient ribosomal and spliceosomal RNA maturation
DA Bernstein, VK Vyas, DE Weinberg… - Proceedings of the …, 2012 - National Acad Sciences
The generation of mature functional RNAs from nascent transcripts requires the precise and
coordinated action of numerous RNAs and proteins. One such protein family, the …
coordinated action of numerous RNAs and proteins. One such protein family, the …