User profiles for D. E. Schones
 | Dustin SchonesCity of Hope Verified email at coh.org Cited by 23069 |
Genome-wide approaches to studying chromatin modifications
DE Schones, K Zhao - Nature Reviews Genetics, 2008 - nature.com
… De novo methylation of promoters that contain CpG islands leads to gene inactivation 23
. DNA methylation of transcription-factor-binding sites can influence their binding 28,29,30 , …
. DNA methylation of transcription-factor-binding sites can influence their binding 28,29,30 , …
Characterization of human epigenomes
Histone modifications play a key role in regulating transcription and thus ultimately regulate
cellular development and differentiation. To understand how histone modifications influence …
cellular development and differentiation. To understand how histone modifications influence …
[HTML][HTML] High-resolution profiling of histone methylations in the human genome
Histone modifications are implicated in influencing gene expression. We have generated
high-resolution maps for the genome-wide distribution of 20 histone lysine and arginine …
high-resolution maps for the genome-wide distribution of 20 histone lysine and arginine …
Combinatorial patterns of histone acetylations and methylations in the human genome
Histones are characterized by numerous posttranslational modifications that influence gene
transcription 1 , 2 . However, because of the lack of global distribution data in higher …
transcription 1 , 2 . However, because of the lack of global distribution data in higher …
[HTML][HTML] Dynamic regulation of nucleosome positioning in the human genome
The positioning of nucleosomes with respect to DNA plays an important role in regulating
transcription. However, nucleosome mapping has been performed for only limited genomic …
transcription. However, nucleosome mapping has been performed for only limited genomic …
[HTML][HTML] Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes
Histone acetyltransferases (HATs) and deacetylases (HDACs) function antagonistically to
control histone acetylation. As acetylation is a histone mark for active transcription, HATs have …
control histone acetylation. As acetylation is a histone mark for active transcription, HATs have …
[PDF][PDF] Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells
… For example, H3K27me3 was not detected on the Il18r1 gene in Th1 cells where it was
expressed. The Il18r1 gene was associated with high amounts of H3K27me3 in Th2 cells, …
expressed. The Il18r1 gene was associated with high amounts of H3K27me3 in Th2 cells, …
A clustering approach for identification of enriched domains from histone modification ChIP-Seq data
Motivation: Chromatin states are the key to gene regulation and cell identity. Chromatin
immunoprecipitation (ChIP) coupled with high-throughput sequencing (ChIP-Seq) is increasingly …
immunoprecipitation (ChIP) coupled with high-throughput sequencing (ChIP-Seq) is increasingly …
Global analysis of the insulator binding protein CTCF in chromatin barrier regions reveals demarcation of active and repressive domains
Insulators are DNA elements that prevent inappropriate interactions between the neighboring
regions of the genome. They can be functionally classified as either enhancer blockers or …
regions of the genome. They can be functionally classified as either enhancer blockers or …
[HTML][HTML] Chromatin signatures in multipotent human hematopoietic stem cells indicate the fate of bivalent genes during differentiation
Histone modifications have been implicated in stem cell maintenance and differentiation.
We have analyzed genome-wide changes in gene expression and histone modifications …
We have analyzed genome-wide changes in gene expression and histone modifications …