… NGS technologies can be used for RNA-seq transcriptomics, the de novo assembly of
non-model organism genomes, and characterizing epigenetic DNA modifications, among many …

Adaptation by natural selection depends on the rates, effects and interactions of many
mutations, making it difficult to determine what proportion of mutations in an evolving lineage are …

Genetic amplification, mutation, and translocation are known to play a causal role in the
upregulation of an oncogene in cancer cells. Here, we report an emerging role of microRNA, the …

… A final strategy for predicting SV is to perform de novo assembly of the sequencing reads
and then map the resulting contigs back to the reference genome to find discrepancies …

Substantial evidence indicates that exposure to bisphenol A (BPA) during early development
may increase breast cancer risk later in life. The changes may persist into puberty and …

Large-scale rearrangements may be important in evolution because they can alter chromosome
organization and gene expression in ways not possible through point mutations. In a …

Isolated populations derived from a common ancestor are expected to diverge genetically
and phenotypically as they adapt to different local environments. To examine this process, 30 …

Resistance to TGF-β is frequently observed in ovarian cancer, and disrupted TGF-β/SMAD4
signaling results in the aberrant expression of downstream target genes in the disease. Our …

… This programmed repression during epithelial differentiation leads to an increased
susceptibility to stochastic de novo methylation, which in turn may act as “seeds” to trigger more …

Evolutionary innovations often arise from complex genetic and ecological interactions, which
can make it challenging to understand retrospectively how a novel trait arose. In a long-…