A new type of gel electrophoresis separates DNA molecules up to 2000 kb with resolutions
exceeding the logarithmic molecular weight dependence of conventional electrophoresis. …

Legumes (Fabaceae or Leguminosae) are unique among cultivated plants for their ability to
carry out endosymbiotic nitrogen fixation with rhizobial bacteria, a process that takes place …

DNA sequencing-by-synthesis (SBS) technology, using a polymerase or ligase enzyme as
its core biochemistry, has already been incorporated in several second-generation DNA …

… K, Zhou S, Reslewic S, Sarkar D, Valouev A, Churas C, Kidd JM, Kohn S, Runnheim R,
Lamers C, Forrest D, Newton MA, Eichler EE, Kent-First M, Surti U, Livny M, Schwartz DC: High-…

Optical Mapping Page 1 interactions between the PRP9, PRP11, and SPP91 proteins we
have characterized here suggest the existence of a highly conserved multimolecular complex …

Physical mapping has been rediscovered as an important component of large-scale sequencing
projects. Restriction maps provide landmark sequences at defined intervals, and high-…

Molecular confinement offers new routes for arraying large DNA molecules, enabling single-molecule
schemes aimed at the acquisition of sequence information. Such schemes can …

The biological functions of many proteins are altered by their covalent attachment to
polypeptide modifiers. The best-known example of this type of modification is ubiquitination. …

We report an improved draft nucleotide sequence of the 2.3-gigabase genome of maize, an
important crop plant and model for biological research. Over 32,000 genes were predicted, …

The bacterium Escherichia coli O157:H7 is a worldwide threat to public health and has been
implicated in many outbreaks of haemorrhagic colitis, some of which included fatalities …