Integrated genome browser: visual analytics platform for genomics

NH Freese, DC Norris, AE Loraine - Bioinformatics, 2016 - academic.oup.com
Motivation: Genome browsers that support fast navigation through vast datasets and
provide interactive visual analytics functions can help scientists achieve deeper insight into …

A tokamak tritium production reactor

…, MS Mckinley, GM Nicholson, DC Norris… - Fusion …, 1997 - Taylor & Francis
A concept is presented for a fusion neutron source based tritium production reactor called
the Tokamak Tritium Production Reactor (TTPR), which could meet the US needs for …

How large must a dose‐optimization trial be?

DC Norris - CPT: Pharmacometrics & Systems Pharmacology, 2023 - Wiley Online Library
Norris DC. Exposing ideological subtext of Fourie Zirkelbach et al (2022). PubPeer. … Norris
DC. One-size-fits-all dosing in oncology wastes money, innovation and lives. Drug Discov …

[HTML][HTML] Dose Titration Algorithm Tuning (DTAT) should supersede 'the'Maximum Tolerated Dose (MTD) in oncology dose-finding trials

DC Norris - F1000Research, 2017 - ncbi.nlm.nih.gov
Background. Absent adaptive, individualized dose-finding in early-phase oncology trials,
subsequent ‘confirmatory’Phase III trials risk suboptimal dosing, with resulting loss of statistical …

Determination of Surfactants Using Ion Pair Extraction of Near-infrared Laser Dyes

MA Roberson, D Andrews-wilberforce, DC Norris… - Analytical …, 1990 - Taylor & Francis
Ionic surfactants and near-infrared laser dyes formed complexes which were extracted into
organic solvents as ion pairs. Surfactants were determined spectrophotometrically by …

The Final Frontier of Younger Abstention: The Judiciary's Abdication of the Federal Court Removal Jurisdiction Statute

DC Norris - Fla. St. UL Rev., 2003 - HeinOnline
Younger abstention is one of several abstention doctrines that the federal courts have used
to refuse to hear cases that properly fall within their jurisdiction. Ever since the humble …

[CITATION][C] Waterfronts: Cities reclaim their edge

A Breen, D Rigby, DC Norris, C Norris - (No Title), 1994 - cir.nii.ac.jp
Norris, Diane Charyk Norris, Charles … 責任表示 Ann Breen and Dick Rigby ; maps by
Diane Charyk Norris and Charles Norris

Costing 'the'MTD

DC Norris - bioRxiv, 2017 - biorxiv.org
Background: Absent adaptive, individualized dose-finding in early-phase oncology trials,
subsequent registration trials risk suboptimal dosing that compromises statistical power and …

Retrospective analysis of a fatal dose-finding trial

DC Norris - arXiv preprint arXiv:2004.12755, 2020 - arxiv.org
The commonplace description of phase 1 clinical trials in oncology as "primarily concerned
with safety" is belied by their near universal adoption of dose-escalation practices which are …

What Were They Thinking? Pharmacologic priors implicit in a choice of 3+ 3 dose-escalation design

DC Norris - arXiv preprint arXiv:2012.05301, 2020 - arxiv.org
… Following Norris [2020], we posit a therapeutic index e κ establishing a fixed ratio between
dose thresholds {… Inaccurate dose selection has pharmacoeconomic consequences [Norris