User profiles for D. A. Relman

David Relman

Stanford University
Verified email at stanford.edu
Cited by 75322

An ecological and evolutionary perspective on human–microbe mutualism and disease

L Dethlefsen, M McFall-Ngai, DA Relman - Nature, 2007 - nature.com
The microbial communities of humans are characteristic and complex mixtures of
microorganisms that have co-evolved with their human hosts. The species that make up these …

The application of ecological theory toward an understanding of the human microbiome

…, L Dethlefsen, BJM Bohannan, DA Relman - Science, 2012 - science.org
… We thank members of the Relman and Bohannan laboratories, and in particular E. Bik, N. …
We thank members of the Relman and Bohannan laboratories, and in particular E. Bik, N. Qvit-…

Sequence-based identification of microbial pathogens: a reconsideration of Koch's postulates

DN Fredericks, DA Relman - Clinical microbiology reviews, 1996 - Am Soc Microbiol
Over 100 years ago, Robert Koch introduced his ideas about how to prove a causal relationship
between a microorganism and a disease. Koch's postulates created a scientific standard …

Diversity of the human intestinal microbial flora

…, M Sargent, SR Gill, KE Nelson, DA Relman - science, 2005 - science.org
The human endogenous intestinal microflora is an essential “organ” in providing nourishment,
regulating epithelial development, and instructing innate immunity; yet, surprisingly, basic …

Metagenomic analysis of the human distal gut microbiome

…, PJ Turnbaugh, BS Samuel, JI Gordon, DA Relman… - science, 2006 - science.org
The human intestinal microbiota is composed of 10 13 to 10 14 microorganisms whose collective
genome (“microbiome”) contains at least 100 times as many genes as our own genome…

[HTML][HTML] Development of the human infant intestinal microbiota

C Palmer, EM Bik, DB DiGiulio, DA Relman… - PLoS …, 2007 - journals.plos.org
… We gratefully acknowledge help from members of the Brown and Relman groups, including
Stephen Popper, Harold Amogan, Les Dethlefsen, and Lina Vennström, as well as valuable …

[HTML][HTML] The pervasive effects of an antibiotic on the human gut microbiota, as revealed by deep 16S rRNA sequencing

L Dethlefsen, S Huse, ML Sogin, DA Relman - PLoS biology, 2008 - journals.plos.org
The human intestinal microbiota is essential to the health of the host and plays a role in
nutrition, development, metabolism, pathogen resistance, and regulation of immune responses. …

Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation

L Dethlefsen, DA Relman - Proceedings of the National …, 2011 - National Acad Sciences
The indigenous human microbiota is essential to the health of the host. Although the microbiota
can be affected by many features of modern life, we know little about its responses to …

[HTML][HTML] A new view of the tree of life

…, Y Amano, K Ise, Y Suzuki, N Dudek, DA Relman… - Nature …, 2016 - nature.com
The tree of life is one of the most important organizing principles in biology 1. Gene surveys
suggest the existence of an enormous number of branches 2, but even an approximation of …

[HTML][HTML] Simple statistical identification and removal of contaminant sequences in marker-gene and metagenomics data

NM Davis, DM Proctor, SP Holmes, DA Relman… - Microbiome, 2018 - Springer
Background The accuracy of microbial community surveys based on marker-gene and
metagenomic sequencing (MGS) suffers from the presence of contaminants—DNA sequences …