User profiles for D. A. Fidock

David Fidock

Professor of Microbiology & Immunology and of Medical Sciences (in Medicine), Columbia …
Verified email at columbia.edu
Cited by 34502

Antimalarial drug discovery: efficacy models for compound screening

DA Fidock, PJ Rosenthal, SL Croft, R Brun… - Nature reviews Drug …, 2004 - nature.com
Increased efforts in antimalarial drug discovery are urgently needed. The goal must be to
develop safe and affordable new drugs to counter the spread of malaria parasites that are …

[HTML][HTML] Malaria: progress, perils, and prospects for eradication

BM Greenwood, DA Fidock, DE Kyle… - The Journal of …, 2008 - Am Soc Clin Investig
There are still approximately 500 million cases of malaria and 1 million deaths from malaria
each year. Yet recently, malaria incidence has been dramatically reduced in some parts of …

Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria

RT Eastman, DA Fidock - Nature Reviews Microbiology, 2009 - nature.com
Plasmodium falciparum resistance to chloroquine and sulphadoxine–pyrimethamine has led
to the recent adoption of artemisinin-based combination therapies (ACTs) as the first line of …

[PDF][PDF] Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance

DA Fidock, T Nomura, AK Talley, RA Cooper… - Molecular cell, 2000 - cell.com
… significantly less free heme available for the formation of toxic complexes with CQ, an
effect that expression of the transfected gene provides the only source of active enzyme (Fidock

[HTML][HTML] A molecular marker for chloroquine-resistant falciparum malaria

…, A Dicko, X Su, T Nomura, DA Fidock… - New England journal …, 2001 - Mass Medical Soc
Background Chloroquine-resistant Plasmodium falciparum malaria is a major health problem,
particularly in sub-Saharan Africa. Chloroquine resistance has been associated in vitro …

Spiroindolones, a potent compound class for the treatment of malaria

…, F Nosten, L Renia, V Dartois, TH Keller, DA Fidock… - science, 2010 - science.org
… the Fidock laboratory in part by the Medicines for Malaria Venture (MMV08/0015; PI D. Fidock).
… Funding for the PfATP4 transfectants was provided to the Fidock laboratory in part by the …

[HTML][HTML] Emergence and clonal expansion of in vitro artemisinin-resistant Plasmodium falciparum kelch13 R561H mutant parasites in Rwanda

…, F Ariey, M Murindahabi, P Ringwald, DA Fidock… - Nature medicine, 2020 - nature.com
Artemisinin resistance (delayed P. falciparum clearance following artemisinin-based
combination therapy), is widespread across Southeast Asia but to date has not been reported in …

Chloroquine Resistance in Plasmodium falciparum Malaria Parasites Conferred by pfcrt Mutations

ABS Sidhu, D Verdier-Pinard, DA Fidock - Science, 2002 - science.org
Plasmodium falciparum chloroquine resistance is a major cause of worldwide increases in
malaria mortality and morbidity. Recent laboratory and clinical studies have associated …

[HTML][HTML] A Worldwide Map of Plasmodium falciparum K13-Propeller Polymorphisms

…, J Straimer, B Witkowski, DA Fidock… - … England Journal of …, 2016 - Mass Medical Soc
Background Recent gains in reducing the global burden of malaria are threatened by the
emergence of Plasmodium falciparum resistance to artemisinins. The discovery that mutations …

K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates

…, F Benoit-Vical, RM Fairhurst, D Menard, DA Fidock - Science, 2015 - science.org
The emergence of artemisinin resistance in Southeast Asia imperils efforts to reduce the global
malaria burden. We genetically modified the Plasmodium falciparum K13 locus using zinc…