User profiles for D. A. Fidock
David FidockProfessor of Microbiology & Immunology and of Medical Sciences (in Medicine), Columbia … Verified email at columbia.edu Cited by 34502 |
Antimalarial drug discovery: efficacy models for compound screening
Increased efforts in antimalarial drug discovery are urgently needed. The goal must be to
develop safe and affordable new drugs to counter the spread of malaria parasites that are …
develop safe and affordable new drugs to counter the spread of malaria parasites that are …
[HTML][HTML] Malaria: progress, perils, and prospects for eradication
There are still approximately 500 million cases of malaria and 1 million deaths from malaria
each year. Yet recently, malaria incidence has been dramatically reduced in some parts of …
each year. Yet recently, malaria incidence has been dramatically reduced in some parts of …
Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria
RT Eastman, DA Fidock - Nature Reviews Microbiology, 2009 - nature.com
Plasmodium falciparum resistance to chloroquine and sulphadoxine–pyrimethamine has led
to the recent adoption of artemisinin-based combination therapies (ACTs) as the first line of …
to the recent adoption of artemisinin-based combination therapies (ACTs) as the first line of …
[PDF][PDF] Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance
DA Fidock, T Nomura, AK Talley, RA Cooper… - Molecular cell, 2000 - cell.com
… significantly less free heme available for the formation of toxic complexes with CQ, an
effect that expression of the transfected gene provides the only source of active enzyme (Fidock …
effect that expression of the transfected gene provides the only source of active enzyme (Fidock …
[HTML][HTML] A molecular marker for chloroquine-resistant falciparum malaria
Background Chloroquine-resistant Plasmodium falciparum malaria is a major health problem,
particularly in sub-Saharan Africa. Chloroquine resistance has been associated in vitro …
particularly in sub-Saharan Africa. Chloroquine resistance has been associated in vitro …
Spiroindolones, a potent compound class for the treatment of malaria
… the Fidock laboratory in part by the Medicines for Malaria Venture (MMV08/0015; PI D. Fidock).
… Funding for the PfATP4 transfectants was provided to the Fidock laboratory in part by the …
… Funding for the PfATP4 transfectants was provided to the Fidock laboratory in part by the …
[HTML][HTML] Emergence and clonal expansion of in vitro artemisinin-resistant Plasmodium falciparum kelch13 R561H mutant parasites in Rwanda
Artemisinin resistance (delayed P. falciparum clearance following artemisinin-based
combination therapy), is widespread across Southeast Asia but to date has not been reported in …
combination therapy), is widespread across Southeast Asia but to date has not been reported in …
Chloroquine Resistance in Plasmodium falciparum Malaria Parasites Conferred by pfcrt Mutations
ABS Sidhu, D Verdier-Pinard, DA Fidock - Science, 2002 - science.org
Plasmodium falciparum chloroquine resistance is a major cause of worldwide increases in
malaria mortality and morbidity. Recent laboratory and clinical studies have associated …
malaria mortality and morbidity. Recent laboratory and clinical studies have associated …
[HTML][HTML] A Worldwide Map of Plasmodium falciparum K13-Propeller Polymorphisms
…, J Straimer, B Witkowski, DA Fidock… - … England Journal of …, 2016 - Mass Medical Soc
Background Recent gains in reducing the global burden of malaria are threatened by the
emergence of Plasmodium falciparum resistance to artemisinins. The discovery that mutations …
emergence of Plasmodium falciparum resistance to artemisinins. The discovery that mutations …
K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates
…, F Benoit-Vical, RM Fairhurst, D Menard, DA Fidock - Science, 2015 - science.org
The emergence of artemisinin resistance in Southeast Asia imperils efforts to reduce the global
malaria burden. We genetically modified the Plasmodium falciparum K13 locus using zinc…
malaria burden. We genetically modified the Plasmodium falciparum K13 locus using zinc…