The nervous system consists of hundreds of billions of neurons interconnected into the
functional neural networks that underlie behaviors. The capacity of a neuron to innervate and …

… Stavoe AKH, Colón-Ramos DA. Netrin instructs synaptic vesicle clustering through Rac
GTPase, MIG-10, and the actin cytoskeleton. J Cell Biol 2012; 197:75 - 88; http://dx.doi.org/…

Synapses are a key component of neural circuits, facilitating rapid and specific signalling
between neurons. Synaptic engineering — the synthetic insertion of new synaptic connections …

Optimal four-dimensional imaging requires high spatial resolution in all dimensions, high
speed and minimal photobleaching and damage. We developed a dual-view, plane …

Neural circuits are assembled through the coordinated innervation of pre- and postsynaptic
partners. We show that connectivity between two interneurons, AIY and RIA, in …

Changes in neuronal activity create local and transient changes in energy demands at
synapses. Here we discover a metabolic compartment that forms in vivo near synapses to meet …

We describe the construction and use of a compact dual-view inverted selective plane
illumination microscope (diSPIM) for time-lapse volumetric (4D) imaging of living samples at …

Inhibitors of apoptosis (IAPs) inhibit caspases, thereby preventing proteolysis of apoptotic
substrates. IAPs occlude the active sites of caspases to which they are bound 1 , 2 , 3 and can …

Autophagy is a cellular degradation process important for neuronal development and
survival. Neurons are highly polarized cells in which autophagosome biogenesis is spatially …

Brain circuits endow behavioral flexibility. Here, we study circuits encoding flexible
chemotaxis in C. elegans, where the animal navigates up or down NaCl gradients (positive or …