User profiles for C. Yau

Christopher Yau

University of Oxford
Verified email at wrh.ox.ac.uk
Cited by 8809

[HTML][HTML] Reporting guidelines for clinical trial reports for interventions involving artificial intelligence: the CONSORT-AI extension

…, R Savage, R Sarkar, SJ Vollmer, C Yau - The Lancet Digital …, 2020 - thelancet.com
The CONSORT 2010 statement provides minimum guidelines for reporting randomised trials.
Its widespread use has been instrumental in ensuring transparency in the evaluation of …

[HTML][HTML] Guidelines for clinical trial protocols for interventions involving artificial intelligence: the SPIRIT-AI extension

…, R Savage, R Sarkar, SJ Vollmer, C Yau - The Lancet Digital …, 2020 - thelancet.com
The SPIRIT 2013 statement aims to improve the completeness of clinical trial protocol
reporting by providing evidence-based recommendations for the minimum set of items to be …

Bayesian statistics and modelling

…, A Gelman, D Veen, J Willemsen, C Yau - Nature Reviews …, 2021 - nature.com
c–e | The prior and posterior distributions for β intercept (part c), the linear effect of age (years),
β age (part d) and \({\beta }_{{{\rm{age}}}^{2}}\) (part e) are shown. For each chain, the first …

[PDF][PDF] The immune landscape of cancer

…, P Spellman, C Benz, JM Stuart, CK Wong, C Yau… - Immunity, 2018 - cell.com
We performed an extensive immunogenomic analysis of more than 10,000 tumors comprising
33 diverse cancer types by utilizing data compiled by TCGA. Across cancer types, we …

[PDF][PDF] An integrated TCGA pan-cancer clinical data resource to drive high-quality survival outcome analytics

…, P Spellman, C Benz, JM Stuart, CK Wong, C Yau… - Cell, 2018 - cell.com
For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic
annotation data along with multi-platform molecular profiles of more than 11,000 human tumors …

[PDF][PDF] Oncogenic signaling pathways in the cancer genome atlas

…, P Spellman, C Benz, JM Stuart, CK Wong, C Yau… - Cell, 2018 - cell.com
Genetic alterations in signaling pathways that control cell-cycle progression, apoptosis, and
cell growth are common hallmarks of cancer, but the extent, mechanisms, and co-…

[PDF][PDF] Driver fusions and their implications in the development and treatment of human cancers

…, P Spellman, C Benz, JM Stuart, CK Wong, C Yau… - Cell reports, 2018 - cell.com
Gene fusions represent an important class of somatic alterations in cancer. We systematically
investigated fusions in 9,624 tumors across 33 cancer types using multiple fusion calling …

[PDF][PDF] Comprehensive characterization of cancer driver genes and mutations

…, P Spellman, C Benz, JM Stuart, CK Wong, C Yau… - Cell, 2018 - cell.com
Identifying molecular cancer drivers is critical for precision oncology. Multiple advanced
algorithms to identify drivers now exist, but systematic attempts to combine and optimize them on …

[PDF][PDF] Cell-of-origin patterns dominate the molecular classification of 10,000 tumors from 33 types of cancer

KA Hoadley, C Yau, T Hinoue, DM Wolf, AJ Lazar… - Cell, 2018 - cell.com
We conducted comprehensive integrative molecular analyses of the complete set of tumors
in The Cancer Genome Atlas (TCGA), consisting of approximately 10,000 specimens and …

[PDF][PDF] Comprehensive molecular portraits of invasive lobular breast cancer

…, A Pastore, H Zhang, M McLellan, C Yau, C Kandoth… - Cell, 2015 - cell.com
Invasive lobular carcinoma (ILC) is the second most prevalent histologic subtype of invasive
breast cancer. Here, we comprehensively profiled 817 breast tumors, including 127 ILC, …