Multinucleate cells are widespread in nature, yet the mechanism by which cells fuse their
plasma membranes is poorly understood. To identify animal fusogens, we performed new …

… Here we show that the C. elegans cell-cell fusion protein EFF-1 is structurally homologous
to viral class II fusion proteins. The 2.6 Acrystal structure of the EFF-1 trimer displays the same …

… the cells for 24 h at 37C. The supernatants containing VSVΔG-HAP2 and VSVΔG-EFF-1
were collected and centrifuged at 600 g for 10 min at 4C to clear cell debris. Virions were …

Cell fusion is fundamental for reproduction and organ formation. Fusion between most C.
elegans epithelial cells is mediated by the EFF-1 fusogen. However, fusion between the …

During cell-cell fusion, two cells' plasma membranes merge, allowing the cytoplasms to mix
and form a syncytium. Little is known about the mechanisms of cell fusion. Here, we asked …

… Because IZUMO1 was expressed fused to Venus in the C terminus, we could follow its
expression; we often observed Venus fluorescence at time points when fusion started taking …

Caenorhabditis elegans proteins AFF-1 and EFF-1 [C. elegans fusion family (CeFF) proteins]
are essential for developmental cell-to-cell fusion and can merge insect cells. To study the …

… To search for fusexins we used the crystallographic structures of C. reinhardtii, A. thaliana, …
only one of its conserved disulfide bonds (C 1 125–C 2 155, corresponding to C147-C210/…

A novel serum 21 kDa haptoglobin-related protein (Hpr) was investigated in patients with
malignant lymphoma, to evaluate its correlation with clinical and histologic features at …

Cell fusion of female and male gametes is the climax of sexual reproduction. In many
organisms, the Hapless 2 (HAP2) family of proteins play a critical role in gamete fusion. We find …