User profiles for C. Várnai

Csilla Várnai

University of Birmingham
Verified email at bham.ac.uk
Cited by 5888

[HTML][HTML] COVID-19 mortality in patients with cancer on chemotherapy or other anticancer treatments: a prospective cohort study

…, AJ Smith, T Starkey, CD Turnbull, C Várnai… - The Lancet, 2020 - thelancet.com
Background Individuals with cancer, particularly those who are receiving systemic anticancer
treatments, have been postulated to be at increased risk of mortality from COVID-19. This …

[HTML][HTML] COVID-19 prevalence and mortality in patients with cancer and the effect of primary tumour subtype and patient demographics: a prospective cohort study

…, C Usborne, C Dobeson, C Thirlwell, C Mitchell… - The Lancet …, 2020 - thelancet.com
Background Patients with cancer are purported to have poor COVID-19 outcomes. However,
cancer is a heterogeneous group of diseases, encompassing a spectrum of tumour …

Cell-cycle dynamics of chromosomal organization at single-cell resolution

T Nagano, Y Lubling, C Várnai, C Dudley, W Leung… - Nature, 2017 - nature.com
… Here we scale up single-cell Hi-C 12 using flow cytometry sorting, a new library preparation
protocol and a new automation scheme, and apply this methodology to thousands of diploid …

Topologically associating domains and chromatin loops depend on cohesin and are regulated by CTCF, WAPL, and PDS5 proteins

G Wutz, C Várnai, K Nagasaka, DA Cisneros… - The EMBO …, 2017 - embopress.org
… In a separate experiment, we analyzed the same cells after 0 and 120 min of auxin treatment
(Fig EV2; all Hi-C libraries analyzed in this study and their properties are listed in Table EV1…

[HTML][HTML] CHiCAGO: robust detection of DNA looping interactions in Capture Hi-C data

J Cairns, P Freire-Pritchett, SW Wingett, C Várnai… - Genome biology, 2016 - Springer
… Capture Hi-C (CHi-C) is a method for profiling chromosomal interactions involving … in CHi-C
data involves a number of statistical challenges that are not observed when using other Hi-C-…

[HTML][HTML] Severity of COVID-19 in children with cancer: report from the United Kingdom Paediatric Coronavirus Cancer Monitoring Project

…, MG McCabe, RS Phillips, CA Stiller, C Várnai… - British journal of …, 2021 - nature.com
Background Children with cancer are frequently immunocompromised. While children are
generally thought to be at less risk of severe SARS-CoV-2 infection than adults, …

Global reorganisation of cis-regulatory units upon lineage commitment of human embryonic stem cells

P Freire-Pritchett, S Schoenfelder, C Várnai… - Elife, 2017 - elifesciences.org
… , alongside the conventional Hi-C profiles additionally generated in this study … -C samples
showed an 11 to 15fold enrichment for promoter-containing interactions over conventional Hi-C

Mortality among adults with cancer undergoing chemotherapy or immunotherapy and infected with COVID-19

C Várnai, C Palles, R Arnold, HM Curley… - JAMA network …, 2022 - jamanetwork.com
Importance Large cohorts of patients with active cancers and COVID-19 infection are needed
to provide evidence of the association of recent cancer treatment and cancer type with …

[HTML][HTML] Multiomic atlas with functional stratification and developmental dynamics of zebrafish cis-regulatory elements

…, T Zehnder, AK Mukarram, C Nepal, C Várnai… - Nature …, 2022 - nature.com
Zebrafish, a popular organism for studying embryonic development and for modeling human
diseases, has so far lacked a systematic functional annotation program akin to those in …

[HTML][HTML] Comparison of Hi-C results using in-solution versus in-nucleus ligation

T Nagano, C Várnai, S Schoenfelder, BM Javierre… - Genome biology, 2015 - Springer
… 4C, 5C and Hi-C have emerged as standard tools to … C, we devised an alternative Hi-C
protocol with ligation in preserved nuclei rather than in solution. Here we directly compare Hi-C