User profiles for C. Tomkins-Tinch

Christopher Tomkins-Tinch

Broad Institute of MIT and Harvard
Verified email at g.harvard.edu
Cited by 4738

[PDF][PDF] Structural and functional analysis of the D614G SARS-CoV-2 spike protein variant

L Yurkovetskiy, X Wang, KE Pascal, C Tomkins-Tinch… - Cell, 2020 - cell.com
The SARS-CoV-2 spike (S) protein variant D614G supplanted the ancestral virus worldwide,
reaching near fixation in a matter of months. Here we show that D614G was more infectious …

[HTML][HTML] Sustainable data analysis with Snakemake

…, B Letcher, MB Hall, CH Tomkins-Tinch… - …, 2021 - ncbi.nlm.nih.gov
… Christopher Tomkins-Tinch has designed and implemented remote storage support (
subsection 2.1) and edited the manuscript. Sven Rahmann has edited the manuscript. Sven …

Bioconda: sustainable and comprehensive software distribution for the life sciences

…, A Sjödin, BA Chapman, J Rowe, CH Tomkins-Tinch… - Nature …, 2018 - nature.com
To the Editor: Bioinformatics software comes in a variety of programming languages and
requires diverse installation methods. This heterogeneity makes management of a software …

Phylogenetic analysis of SARS-CoV-2 in Boston highlights the impact of superspreading events

…, G Adams, T Fink, CH Tomkins-Tinch… - Science, 2021 - science.org
INTRODUCTION We used genomic epidemiology to investigate the introduction and spread
of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the Boston area …

Zika virus evolution and spread in the Americas

…, A Gladden-Young, AE Lin, CH Tomkins-Tinch… - Nature, 2017 - nature.com
Although the recent Zika virus (ZIKV) epidemic in the Americas and its link to birth defects
have attracted a great deal of attention 1 , 2 , much remains unknown about ZIKV disease …

Genomic epidemiology reveals multiple introductions of Zika virus into the United States

…, DJ Park, J Qu, SF Schaffner, C Tomkins-Tinch… - Nature, 2017 - nature.com
Zika virus (ZIKV) is causing an unprecedented epidemic linked to severe congenital abnormalities
1 , 2 . In July 2016, mosquito-borne ZIKV transmission was reported in the continental …

[PDF][PDF] Comparative transmissibility of SARS-CoV-2 variants delta and alpha in New England, USA

…, KJ Siddle, C Loreth, G Adams, CH Tomkins-Tinch… - Cell Reports …, 2022 - cell.com
The SARS-CoV-2 Delta variant rose to dominance in mid-2021, likely propelled by an
estimated 40%–80% increased transmissibility over Alpha. To investigate if this ostensible …

[HTML][HTML] Ebola virus epidemiology, transmission, and evolution during seven months in Sierra Leone

…, A Sanchez, D Wang, I Jungreis, C Tomkins-Tinch… - Cell, 2015 - cell.com
The 2013–2015 Ebola virus disease (EVD) epidemic is caused by the Makona variant of
Ebola virus (EBOV). Early in the epidemic, genome sequencing provided insights into virus …

[PDF][PDF] Profiling SARS-CoV-2 HLA-I peptidome reveals T cell epitopes from out-of-frame ORFs

…, D Leistritz-Edwards, MR Durkin, CH Tomkins-Tinch… - Cell, 2021 - cell.com
T cell-mediated immunity plays an important role in controlling SARS-CoV-2 infection, but the
repertoire of naturally processed and presented viral epitopes on class I human leukocyte …

SARS-CoV-2 Spike protein variant D614G increases infectivity and retains sensitivity to antibodies that target the receptor binding domain

L Yurkovetskiy, KE Pascal, C Tomkins-Tinch, T Nyalile… - BioRxiv, 2020 - biorxiv.org
Virus genome sequence variants that appear over the course of an outbreak can be exploited
to map the trajectory of the virus from one susceptible host to another. While such variants …