[HTML][HTML] Biocompatibility of chitosan carriers with application in drug delivery
S Rodrigues, M Dionísio, C Remunan Lopez… - Journal of functional …, 2012 - mdpi.com
Chitosan is one of the most used polysaccharides in the design of drug delivery strategies
for administration of either biomacromolecules or low molecular weight drugs. For these …
for administration of either biomacromolecules or low molecular weight drugs. For these …
Microencapsulated chitosan nanoparticles for lung protein delivery
A Grenha, B Seijo, C Remuñán-López - European journal of …, 2005 - Elsevier
… were maintained at 160 ± 2 C (when mannitol was used as excipient) and 135 ± 2 C (for
lactose), resulting in outlet temperatures of 108 ± 3 C and 85 ± 3 C, respectively. The airflow …
lactose), resulting in outlet temperatures of 108 ± 3 C and 85 ± 3 C, respectively. The airflow …
Glucomannan, a promising polysaccharide for biopharmaceutical purposes
…, D Teijeiro-Osorio, C Remuñán-López… - European Journal of …, 2009 - Elsevier
Over the last few decades, polysaccharides have gained increasing attention in the biomedical
and drug delivery fields. Among them, glucomannan (GM), has become a particularly …
and drug delivery fields. Among them, glucomannan (GM), has become a particularly …
Microencapsulated chitosan nanoparticles for pulmonary protein delivery: in vivo evaluation of insulin-loaded formulations
…, D Carrión-Recio, B Seijo, C Remuñán-López - Journal of controlled …, 2012 - Elsevier
This work presents a new dry powder system consisting of microencapsulated protein-loaded
chitosan nanoparticles (CS NPs). The developed system was evaluated in vivo in rats in …
chitosan nanoparticles (CS NPs). The developed system was evaluated in vivo in rats in …
Mechanical, water uptake and permeability properties of crosslinked chitosan glutamate and alginate films
C Remuñán-López, R Bodmeier - Journal of controlled release, 1997 - Elsevier
… The films were dried for 48 h at room temperature and then for 24 h in an oven at 40C (area
of casting=18×10 cm 2 ; standard formulation: casting weight=73 g; total solids content=3.65 …
of casting=18×10 cm 2 ; standard formulation: casting weight=73 g; total solids content=3.65 …
Chitosan nanoparticles are compatible with respiratory epithelial cells in vitro
…, B Seijo, GP Martin, C Remuñán-López… - European Journal of …, 2007 - Elsevier
… temperatures of 160 ± 2 C and 108 ± 3 C, respectively. The air … Each analysis lasted 180 s
and was performed at 25 C with a … , 15 C) and sediments were lyophilised (24 h at −34 C and …
and was performed at 25 C with a … , 15 C) and sediments were lyophilised (24 h at −34 C and …
Design of microencapsulated chitosan microspheres for colonic drug delivery
ML Lorenzo-Lamosa, C Remunan-Lopez… - Journal of controlled …, 1998 - Elsevier
Among the different approaches to achieve colon-selective drug delivery, the use of polymers,
specifically biodegraded by colonic bacteria, holds great promise. In this work a new …
specifically biodegraded by colonic bacteria, holds great promise. In this work a new …
Design and evaluation of chitosan/ethylcellulose mucoadhesive bilayered devices for buccal drug delivery
C Remuñán-López, A Portero, JL Vila-Jato… - Journal of controlled …, 1998 - Elsevier
This paper describes the preparation of new buccal bilayered devices comprising a drug-containing
mucoadhesive layer and a drug-free backing layer, by two different methods. …
mucoadhesive layer and a drug-free backing layer, by two different methods. …
The potential of chitosan for pulmonary drug delivery
…, S Al-Qadi, B Seijo, C Remuñán-López - Journal of Drug Delivery …, 2010 - Elsevier
The administration of drugs through the pulmonary route offers great advantages, but it also
requires overcoming many challenges. There is a need to develop appropriate carriers to …
requires overcoming many challenges. There is a need to develop appropriate carriers to …
Microspheres containing lipid/chitosan nanoparticles complexes for pulmonary delivery of therapeutic proteins
A Grenha, C Remuñán-López, ELS Carvalho… - European Journal of …, 2008 - Elsevier
Chitosan/tripolyphosphate nanoparticles have already been demonstrated to promote peptide
absorption through several mucosal surfaces. We have recently developed a new drug …
absorption through several mucosal surfaces. We have recently developed a new drug …