International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptors
The three peroxisome proliferator-activated receptors (PPARs) are ligand-activated
transcription factors of the nuclear hormone receptor superfamily. They share a high degree of …
transcription factors of the nuclear hormone receptor superfamily. They share a high degree of …
Music performance
C Palmer - Annual review of psychology, 1997 - annualreviews.org
… As interpretations of the melodic voice changed across performances, the voice that
preceded other notated simultaneities changed accordingly (Palmer 1996b). Melody leads may …
preceded other notated simultaneities changed accordingly (Palmer 1996b). Melody leads may …
Sleep and emotion regulation: An organizing, integrative review
A growing body of research suggests that disrupted sleep is a robust risk and maintenance
factor for a range of psychiatric conditions. One explanatory mechanism linking sleep and …
factor for a range of psychiatric conditions. One explanatory mechanism linking sleep and …
A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity
Obesity is a serious international health problem that increases the risk of several common
diseases. The genetic factors predisposing to obesity are poorly understood. A genome-wide …
diseases. The genetic factors predisposing to obesity are poorly understood. A genome-wide …
The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans
Understanding the functional consequences of genetic variation, and how it affects complex
human disease and quantitative traits, remains a critical challenge for biomedicine. We …
human disease and quantitative traits, remains a critical challenge for biomedicine. We …
Genetic studies of body mass index yield new insights for obesity biology
…, C Medina-Gomez, SE Medland, MA Nalls, CD Palmer… - Nature, 2015 - nature.com
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of
obesity better, here we conduct a genome-wide association study and Metabochip meta-…
obesity better, here we conduct a genome-wide association study and Metabochip meta-…
Hundreds of variants clustered in genomic loci and biological pathways affect human height
…, TW Winkler, ME Goddard, K Sin Lo, C Palmer… - Nature, 2010 - nature.com
Most common human traits and diseases have a polygenic pattern of inheritance: DNA
sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA…
sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA…
Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis
CNA Palmer, AD Irvine, A Terron-Kwiatkowski, Y Zhao… - Nature …, 2006 - nature.com
… Reactions were amplified as follows: 94 C (12 min), one cycle; 94 C (15 s), 58 C (30 s) and
72 C (45 s), 30 cycles; and 72 C (5 min), one cycle. Fragments were diluted 1:60 and sized …
72 C (45 s), 30 cycles; and 72 C (5 min), one cycle. Fragments were diluted 1:60 and sized …
[PDF][PDF] Molecular profiling reveals biologically discrete subsets and pathways of progression in diffuse glioma
Therapy development for adult diffuse glioma is hindered by incomplete knowledge of somatic
glioma driving alterations and suboptimal disease classification. We defined the complete …
glioma driving alterations and suboptimal disease classification. We defined the complete …
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
…, N Narisu, P Nilsson, KR Owen, CNA Palmer… - Nature …, 2008 - nature.com
Genome-wide association (GWA) studies have identified multiple loci at which common variants
modestly but reproducibly influence risk of type 2 diabetes (T2D) 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , …
modestly but reproducibly influence risk of type 2 diabetes (T2D) 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , …