… A full blood count was done and an aliquot of blood stored at −80C for later genetic tests.
Culture bottles were weighed before and after blood inoculation and processed by an …

Background Many investigators have suggested that malaria infection predisposes individuals
to bacteraemia. We tested this hypothesis with mendelian randomisation studies of …

INTRODUCTION Malaria parasites cause human disease by invading and replicating inside
red blood cells. In the case of Plasmodium falciparum, this can lead to severe forms of …

Although malaria is widely considered a major cause of death in young children born with
sickle cell anemia (SCA) in sub-Saharan Africa, this is poorly quantified. We attempted to …

10.7554/eLife.15266.001 Similarity between two individuals in the combination of genetic
markers along their chromosomes indicates shared ancestry and can be used to identify …

Combining data from genome-wide association studies (GWAS) conducted at different
locations, using genotype imputation and fixed-effects meta-analysis, has been a powerful …

Host genetic factors can confer resistance against malaria 1 , raising the question of whether
this has led to evolutionary adaptation of parasite populations. Here we searched for …

Background Human genetic factors are important determinants of malaria risk. We investigated
associations between multiple candidate polymorphisms—many related to the structure …

… We did this study in Kilifi County, Kenya, where the G6PD c.202T allele is the only significant
cause of G6PD deficiency. We tested the associations between G6PD deficiency and …

10.7554/eLife.15085.001 Glucose-6-phosphate dehydrogenase (G6PD) deficiency is believed
to confer protection against Plasmodium falciparum malaria, but the precise nature of the …