Across the animal kingdom, gastrulation represents a key developmental event during which
embryonic pluripotent cells diversify into lineage-specific precursors that will generate the …

Cell state transitions are prevalent in biology, playing a fundamental role in development,
homeostasis and repair. Dysregulation of cell state transitions can lead to or occur in a wide …

… OF rats displaying similar decreases in liver SCD1 induced by either ip (C and D) or intraportal
(E and F) ASO. (C) ip Scd1 ASO markedly suppressed Scd1 expression in liver and white …

The mouse inner cell mass (ICM) segregates into the epiblast and primitive endoderm (PrE)
lineages coincident with implantation of the embryo. The epiblast subsequently undergoes …

Anemia in oncology patients is often considered a side effect of cancer therapy; however, it
may occur before any antineoplastic treatment (cancer-related anemia). This study was …

… The tubes were directly centrifuged for 10 min in a refrigerated (10C) table-top centrifuge at
500 g. Serum samples were immediately stored at –30C until analysis. Serum levels of leptin …

Mouse embryonic stem (ES) cells are locked into self-renewal by shielding from inductive
cues. Release from this ground state in minimal conditions offers a system for delineating …

Detailed studies of the embryo allow an increasingly mechanistic understanding of development,
which has proved of profound relevance to human disease. The last decade has seen …

A fundamental challenge when studying biological systems is the description of cell state
dynamics. During transitions between cell states, a multitude of parameters may change – from …

The transcription factor Oct4 is required in vitro for establishment and maintenance of embryonic
stem cells and for reprogramming somatic cells to pluripotency. In vivo, it prevents the …