User profiles for C. Meplan

Catherine Meplan

Senior Lecturer in Genetics, Newcastle University
Verified email at ncl.ac.uk
Cited by 3735

Selenium and viral infection: are there lessons for COVID-19?

G Bermano, C Méplan, DK Mercer… - British journal of …, 2021 - cambridge.org
… , of micronutrients including Se, Zn and vitamins A, B6, B12 and E have been linked to
adverse outcomes in viral infection(87) and levels of these micronutrients, as well as vitamins C

Redox signalling and transition metals in the control of the p53 pathway

C Méplan, MJ Richard, P Hainaut - Biochemical pharmacology, 2000 - Elsevier
… modification of the C-terminus (acetylation, phosphorylation), by binding of heterologous
proteins, or by reaction with C-terminal-specific monoclonal antibodies such as PAb421 21, 22. …

Selenium and cancer: a story that should not be forgotten-insights from genomics

C Méplan, J Hesketh - Advances in Nutrition and Cancer, 2014 - Springer
… In GPX4, rs713041 has C/T allelic variants and both variants … -2 cell extracts, the C variant
shows stronger binding than the … 2 cells, the T- and C-variant sequences showed differences in …

Two common single nucleotide polymorphisms in the gene encoding β‐carotene 15, 15′‐monoxygenase alter β‐carotene metabolism in female volunteers

WC Leung, S Hessel, C Meplan, J Flint… - The FASEB …, 2009 - Wiley Online Library
… The following PCR conditions were used: 30 s at 95C for 1 cycle; 30 s at 95C, 1 min at 52C,
and 7 min at 68C for 18 cycles; and 14 min at 68C for 1 cycle. The validity of all point …

Metalloregulation of the tumor suppressor protein p53: zinc mediates the renaturation of p53 after exposure to metal chelators in vitro and in intact cells

C Méplan, MJ Richard, P Hainaut - Oncogene, 2000 - nature.com
C+Zn, lanes 2 and 5), or CdCl 2 at 30 μM (C+Cd, lanes 3 and 6). The DNA-binding activity
of nuclear protein extracts (40 μg proteins/binding experiment) was analysed by EMSA. White …

Selenium status is associated with colorectal cancer risk in the European prospective investigation of cancer and nutrition cohort

…, M Jenab, L Schomburg, C Méplan… - … journal of cancer, 2015 - Wiley Online Library
… Serum samples are stored at the International Agency for Research on Cancer (IARC) at
−196C under liquid nitrogen for all countries except Denmark (−150C, nitrogen vapor). Written …

[HTML][HTML] Cadmium induces conformational modifications of wild-type p53 and suppresses p53 response to DNA damage in cultured cells

C Méplan, K Mann, P Hainaut - Journal of Biological Chemistry, 1999 - ASBMB
… Activation requires post-translational modifications at both the N and C terminus of the protein,
including changes in phosphorylation, acetylation, and binding to heterologous proteins ( …

Genetic variants in selenoprotein genes increase risk of colorectal cancer

C Méplan, DJ Hughes, B Pardini, A Naccarati… - …, 2010 - academic.oup.com
… In addition, increased risk of CRC has been found to be associated with the C variant allele
… rs713041 in the GPX4 gene results in a C/T base change in the 3′-UTR GPx4 messenger …

Four selenoproteins, protein biosynthesis, and Wnt signalling are particularly sensitive to limited selenium intake in mouse colon

…, C Meplan, L Schomburg, C Evelo… - Molecular nutrition & …, 2009 - Wiley Online Library
… Plasma and tissues freeze clamped in liquid nitrogen were stored at −80C. … were expressed
at a level that could be measured with sufficient sensitivity (c T -value<30, Table 4). Seven of …

Effects of selenium status and polymorphisms in selenoprotein genes on prostate cancer risk in a prospective study of European men

A Steinbrecher, C Méplan, J Hesketh… - … , biomarkers & prevention, 2010 - AACR
… We further evaluated potential effect modification by vitamin E intake, vitamin C intake, β-carotene
intake, or smoking status. Additionally, we did spline regression to modulate a …