Background: Patients with ALS are often told that the disease spares cognition; however,
recent evidence suggests deficits in frontal executive skills occur in a sizable minority of ALS …

Patients with frontotemporal dementia (FTD) with no known diagnosis of ALS or family history
of ALS were clinically and electrophysiologically assessed for the presence of ALS. Of 36 …

To elucidate the genetic architecture of amyotrophic lateral sclerosis (ALS) and find
associated loci, we assembled a custom imputation reference panel from whole-genome-sequenced …

Amyotrophic lateral sclerosis (ALS) is increasingly recognized to be a multisystem disorder
which includes both clinical and neuropathological features of a frontotemporal lobar …

Pedigrees from 269 patients with frontotemporal lobar degeneration (FTLD), including
frontotemporal dementia (FTD), FTD with ALS (FTD/ALS), progressive nonfluent aphasia, …

Background A rare variant in the Triggering Receptor Expressed on Myeloid cells 2 (TREM2)
gene has been reported to be a genetic risk factor for Alzheimer’s disease by two …

Background: Mitochondrial dysfunction occurs early in the course of ALS, and the
mitochondria may be an important site for therapeutic intervention. Creatine stabilizes the …

Objective: To determine whether patients with ALS–frontotemporal lobar dementia (FTLD)
have a shorter survival and are less compliant with recommended treatments than those with …

Objective: To investigate the patterns of MRI brain atrophy in patients with ALS with and without
clinically evident frontotemporal lobar dementia (FTLD) using voxel-based morphometry (…

Background Approximately 90% of persons with amyotrophic lateral sclerosis (ALS) have
the sporadic form, which may be caused by the interaction of multiple environmental factors …