Serpins are a broadly distributed family of protease inhibitors that use a conformational
change to inhibit target enzymes. They are central in controlling many important proteolytic …

Low-resource settings are disproportionately burdened by infectious diseases and
antimicrobial resistance. Good quality clinical bacteriology through a well functioning reference …

Growing data suggest that antimicrobial-resistant bacterial infections are common in low-
and middle-income countries. This review summarises the microbiology of key bacterial …

Gamma-aminobutyric acid (GABA) is synthesized by two isoforms of the pyridoxal 5′-phosphate–dependent
enzyme glutamic acid decarboxylase (GAD65 and GAD67). GAD67 is …

Background Real-time PCR is recommended to detect SARS-CoV-2 infection. However,
PCR availability is restricted in most countries. Rapid diagnostic tests are considered …

… for 2 years at a temperature of 37C and for 6 months at 40C. The placebo was the same …
The vaccine and placebo were stored at 2C to 8C from the time of shipping to arrival at the …

… (C) Immunoblot showing relative changes in β-pSer108 and α-pThr172 as a result of induction
… Activities of untreated AMPK preparations immunoblotted in (C) were measured with A-…

… Cells were grown to an optical density (OD 600 ) of ~1 at 28 C and induced with 100 μM
IPTG at 16 C overnight. Cell pellets were resuspended in 25 mM Tris HCl pH 8.0, 300 mM NaCl, …

… However, AMPK-inhibitory tool compounds are largely limited to compound C, which has a
… markedly lower kinase promiscuity than compound C and inhibits cellular AMPK signaling. …

… c, The thermosensitive tor2.51 strain was grown at the restrictive temperature (37 C) for 3 h
to inhibit TORC1. Both TORC1 and TORC2 signalling in wild-type S. pombe were inhibited by …