User profiles for C. Kapourani

Chantriolnt-Andreas Kapourani

Postdoc, IGC & School of Informatics, University of Edinburgh
Verified email at ed.ac.uk
Cited by 1260

[HTML][HTML] scNMT-seq enables joint profiling of chromatin accessibility DNA methylation and transcription in single cells

SJ Clark, R Argelaguet, CA Kapourani… - Nature …, 2018 - nature.com
Parallel single-cell sequencing protocols represent powerful methods for investigating regulatory
relationships, including epigenome-transcriptome interactions. Here, we report a single…

[PDF][PDF] Glioblastomas acquire myeloid-affiliated transcriptional programs via epigenetic immunoediting to elicit immune evasion

…, F Galvez-Cancino, N McGivern, E Güç, CA Kapourani… - Cell, 2021 - cell.com
Glioblastoma multiforme (GBM) is an aggressive brain tumor for which current immunotherapy
approaches have been unsuccessful. Here, we explore the mechanisms underlying …

Multi-omics profiling of mouse gastrulation at single-cell resolution

…, H Mohammed, LC Stapel, C Krueger, CA Kapourani… - Nature, 2019 - nature.com
Formation of the three primary germ layers during gastrulation is an essential step in the
establishment of the vertebrate body plan and is associated with major transcriptional changes …

[HTML][HTML] Melissa: Bayesian clustering and imputation of single-cell methylomes

CA Kapourani, G Sanguinetti - Genome biology, 2019 - Springer
Measurements of single-cell methylation are revolutionizing our understanding of epigenetic
control of gene expression, yet the intrinsic data sparsity limits the scope for quantitative …

Multimodal decoding of human liver regeneration

…, JR Wilson-Kanamori, JR Portman, CA Kapourani… - bioRxiv, 2023 - biorxiv.org
… PNR, peri-necrotic region; RVR, remnant viable region c, Quantification of necrotic area in
human healthy (n=9) and APAP… We thank C. Nicol for help with figure illustrations. We thank N. …

Higher order methylation features for clustering and prediction in epigenomic studies

CA Kapourani, G Sanguinetti - Bioinformatics, 2016 - academic.oup.com
… at a single cytosine can be naturally modeled with a Binomial distribution, where the number
of successes represents the number of reads on which the cytosine actually appears as C, …

[HTML][HTML] scMET: Bayesian modeling of DNA methylation heterogeneity at single-cell resolution

CA Kapourani, R Argelaguet, G Sanguinetti… - Genome Biology, 2021 - Springer
… Throughout our analyses, we assume x j =(1,C j ), where C j denotes the CpG density for
feature j. However, scMET is flexible and users can introduce other feature-specific covariates. …

BPRMeth: a flexible Bioconductor package for modelling methylation profiles

CA Kapourani, G Sanguinetti - Bioinformatics, 2018 - academic.oup.com
Motivation High-throughput measurements of DNA methylation are increasingly becoming a
mainstay of biomedical investigations. While the methylation status of individual cytosines …

Single cell multi-omics profiling reveals a hierarchical epigenetic landscape during mammalian germ layer specification

…, C Krueger, CA Kapourani, Y Xiang, C Hanna… - BioRxiv, 2019 - biorxiv.org
Formation of the three primary germ layers during gastrulation is an essential step in the
establishment of the vertebrate body plan. Recent studies employing single cell RNA-…

Gelatin nanoparticles for NSAID systemic administration: Quality by design and artificial neural networks implementation

AE Koletti, E Tsarouchi, A Kapourani… - International Journal of …, 2020 - Elsevier
… g u c h i s q u a r e r o o t m o d e l : D t = D 0 + k H t 1 / 2 (8) - K o r s m e y e r - P e p p a s m
o d e l : D t / D ∞ = D 0 + k P t n (9) - H i x o n - C r o w e l l m o d e l : D t 1 3 = D 0 1 3 - k H C t …