User profiles for C. Kapourani
Chantriolnt-Andreas KapouraniPostdoc, IGC & School of Informatics, University of Edinburgh Verified email at ed.ac.uk Cited by 1260 |
[HTML][HTML] scNMT-seq enables joint profiling of chromatin accessibility DNA methylation and transcription in single cells
Parallel single-cell sequencing protocols represent powerful methods for investigating regulatory
relationships, including epigenome-transcriptome interactions. Here, we report a single…
relationships, including epigenome-transcriptome interactions. Here, we report a single…
[PDF][PDF] Glioblastomas acquire myeloid-affiliated transcriptional programs via epigenetic immunoediting to elicit immune evasion
Glioblastoma multiforme (GBM) is an aggressive brain tumor for which current immunotherapy
approaches have been unsuccessful. Here, we explore the mechanisms underlying …
approaches have been unsuccessful. Here, we explore the mechanisms underlying …
Multi-omics profiling of mouse gastrulation at single-cell resolution
Formation of the three primary germ layers during gastrulation is an essential step in the
establishment of the vertebrate body plan and is associated with major transcriptional changes …
establishment of the vertebrate body plan and is associated with major transcriptional changes …
[HTML][HTML] Melissa: Bayesian clustering and imputation of single-cell methylomes
CA Kapourani, G Sanguinetti - Genome biology, 2019 - Springer
Measurements of single-cell methylation are revolutionizing our understanding of epigenetic
control of gene expression, yet the intrinsic data sparsity limits the scope for quantitative …
control of gene expression, yet the intrinsic data sparsity limits the scope for quantitative …
Multimodal decoding of human liver regeneration
…, JR Wilson-Kanamori, JR Portman, CA Kapourani… - bioRxiv, 2023 - biorxiv.org
… PNR, peri-necrotic region; RVR, remnant viable region c, Quantification of necrotic area in
human healthy (n=9) and APAP… We thank C. Nicol for help with figure illustrations. We thank N. …
human healthy (n=9) and APAP… We thank C. Nicol for help with figure illustrations. We thank N. …
Higher order methylation features for clustering and prediction in epigenomic studies
CA Kapourani, G Sanguinetti - Bioinformatics, 2016 - academic.oup.com
… at a single cytosine can be naturally modeled with a Binomial distribution, where the number
of successes represents the number of reads on which the cytosine actually appears as C, …
of successes represents the number of reads on which the cytosine actually appears as C, …
[HTML][HTML] scMET: Bayesian modeling of DNA methylation heterogeneity at single-cell resolution
… Throughout our analyses, we assume x j =(1,C j ), where C j denotes the CpG density for
feature j. However, scMET is flexible and users can introduce other feature-specific covariates. …
feature j. However, scMET is flexible and users can introduce other feature-specific covariates. …
BPRMeth: a flexible Bioconductor package for modelling methylation profiles
CA Kapourani, G Sanguinetti - Bioinformatics, 2018 - academic.oup.com
Motivation High-throughput measurements of DNA methylation are increasingly becoming a
mainstay of biomedical investigations. While the methylation status of individual cytosines …
mainstay of biomedical investigations. While the methylation status of individual cytosines …
Single cell multi-omics profiling reveals a hierarchical epigenetic landscape during mammalian germ layer specification
…, C Krueger, CA Kapourani, Y Xiang, C Hanna… - BioRxiv, 2019 - biorxiv.org
Formation of the three primary germ layers during gastrulation is an essential step in the
establishment of the vertebrate body plan. Recent studies employing single cell RNA-…
establishment of the vertebrate body plan. Recent studies employing single cell RNA-…
Gelatin nanoparticles for NSAID systemic administration: Quality by design and artificial neural networks implementation
AE Koletti, E Tsarouchi, A Kapourani… - International Journal of …, 2020 - Elsevier
… g u c h i s q u a r e r o o t m o d e l : D t = D 0 + k H t 1 / 2 (8) - K o r s m e y e r - P e p p a s m
o d e l : D t / D ∞ = D 0 + k P t n (9) - H i x o n - C r o w e l l m o d e l : D t 1 3 = D 0 1 3 - k H C t …
o d e l : D t / D ∞ = D 0 + k P t n (9) - H i x o n - C r o w e l l m o d e l : D t 1 3 = D 0 1 3 - k H C t …