Nonsteroidal anti-inflammatory drug gastropathy

CJ Hawkey - Gastroenterology, 2000 - Elsevier
… with antral changes described as type C gastritis. Type C gastritis is characterized by epithelial…
There is no evidence that type C gastritis causes clinically evident symptoms or pathology. …

COX-1 and COX-2 inhibitors

CJ Hawkey - Best Practice & Research Clinical Gastroenterology, 2001 - Elsevier
By inhibiting prostaglandin synthesis, non-steroidal anti-inflammatory drugs (NSAIDs) cause
mucosal damage, ulceration and ulcer complication throughout the gastrointestinal tract. …

Probiotics for maintenance of remission in Crohn's disease

VE Rolfe, PJ Fortun, CJ Hawkey… - Cochrane Database …, 2006 - cochranelibrary.com
c) Unpublished literature from on‐going trials was identified by correspondence with …
Secondary outcomes were adverse events and tolerability, and effects on C‐reactive protein. …

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

…, C Gieger, J Glas, T Haritunians, A Hart, C Hawkey… - Nature, 2012 - nature.com
Crohn’s disease and ulcerative colitis, the two common forms of inflammatory bowel disease
(IBD), affect over 2.5 million people of European ancestry, with rising prevalence in other …

[HTML][HTML] Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis

…, B Davis, R Day, MB Ferraz, CJ Hawkey… - … England Journal of …, 2000 - Mass Medical Soc
Background Each year, clinical upper gastrointestinal events occur in 2 to 4 percent of patients
who are taking nonselective nonsteroidal antiinflammatory drugs (NSAIDs). We assessed …

Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials.

…, H Halls, E Hawk, C Hawkey, C Hennekens… - Lancet (London …, 2013 - europepmc.org
… In particular, C Baigent was chief investigator of the Study of Heart and Renal Protection of
C Hawkey reports previously having received grants or honoraria from Merck, Pfizer, and …

Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease

…, M Parkes, CW Lees, H Uhlig, C Hawkey… - Nature …, 2017 - nature.com
Genetic association studies have identified 215 risk loci for inflammatory bowel disease 1 ,
2 , 3 , 4 , 5 , 6 , 7 , 8 , thereby uncovering fundamental aspects of its molecular biology. We …

COX-2 inhibitors

CJ Hawkey - The Lancet, 1999 - thelancet.com
In the past 100 years aspirin has demonstrated its value as an analgesic, anti-inflammatory,
and antithrombotic agent. However, by 1938, it was clear that aspirin was gastrotoxic. Non-…

[HTML][HTML] A comparison of omeprazole with ranitidine for ulcers associated with nonsteroidal antiinflammatory drugs

…, AJ Swannell, CJ Hawkey - … England Journal of …, 1998 - Mass Medical Soc
Background Suppressing acid secretion is thought to reduce the risk of ulcers associated
with regular use of nonsteroidal antiinflammatory drugs (NSAIDs), but the best means of …

[HTML][HTML] Omeprazole compared with misoprostol for ulcers associated with nonsteroidal antiinflammatory drugs

CJ Hawkey, JA Karrasch, L Szczepański… - … England Journal of …, 1998 - Mass Medical Soc
Background Misoprostol is effective for ulcers associated with the use of nonsteroidal
antiinflammatory drugs (NSAIDs) but is often poorly tolerated because of diarrhea and abdominal …