Objectives To assess the overall effect of vitamin D supplementation on risk of acute respiratory
tract infection, and to identify factors modifying this effect. Design Systematic review and …

Psoriasis, a papulosquamous skin disease, was originally thought of as a disorder primarily
of epidermal keratinocytes, but is now recognised as one of the commonest immune-…

The worldwide incidence and prevalence of psoriasis is poorly understood. To better understand
this, we performed a systematic review of published population-based studies on the …

Zebrafish have become a popular organism for the study of vertebrate gene function 1 , 2 .
The virtually transparent embryos of this species, and the ability to accelerate genetic studies …

The murine monoclonal antibody OC 125 reacts with an antigen (CA 125) common to most
nonmucinous epithelial ovarian carcinomas. An assay has been developed to detect CA 125 …

The human X chromosome has a unique biology that was shaped by its evolution as the sex
chromosome shared by males and females. We have determined 99.3% of the euchromatic …

Introduction In the real-world APPRECIATE study (NCT02740218), most patients with
psoriasis demonstrated notable improvements on disease severity measures and reported …

Background Interleukin-17A is considered to be central to the pathogenesis of psoriasis. We
evaluated secukinumab, a fully human anti–interleukin-17A monoclonal antibody, in …

Daily numbers of deaths at a regional level were collected in 16 European countries.
Summer mortality was analyzed for the reference period 1998–2002 and for 2003. More than …

… Methotrexate monotherapy was investigated in three of these studies, one of which was
assigned a grade of evidence of A2,61 and two of which were assigned a grade of evidence …