User profiles for C. Frezza
Christian FrezzaCECAD, University of Cologne Verified email at uni-koeln.de Cited by 43739 |
A roadmap for interpreting 13C metabolite labeling patterns from cells
… of 13 C labeling patterns (without formal 13 C flux analysis) … C labeling patterns as 13 C
tracer analysis. Here, we discuss selected important aspects to consider when performing 13 C …
tracer analysis. Here, we discuss selected important aspects to consider when performing 13 C …
[PDF][PDF] A unifying mechanism for mitochondrial superoxide production during ischemia-reperfusion injury
… (C) The factors that favor RET at complex I during reperfusion. The condition to be met for
RET to occur is that 4Dp>2DEh. The rapid oxidation of the succinate that accumulates during …
RET to occur is that 4Dp>2DEh. The rapid oxidation of the succinate that accumulates during …
[HTML][HTML] Designing a broad-spectrum integrative approach for cancer prevention and treatment
…, C Fimognari, GL Firestone, C Frezza… - Seminars in cancer …, 2015 - Elsevier
Targeted therapies and the consequent adoption of “personalized” oncology have achieved
notable successes in some cancers; however, significant problems remain with this …
notable successes in some cancers; however, significant problems remain with this …
Succinate is an inflammatory signal that induces IL-1β through HIF-1α
Macrophages activated by the Gram-negative bacterial product lipopolysaccharide switch
their core metabolism from oxidative phosphorylation to glycolysis 1 . Here we show that …
their core metabolism from oxidative phosphorylation to glycolysis 1 . Here we show that …
Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS
… 13 C-… C-aspartate infusion significantly increased the 13 C-succinate content of the
ischaemic myocardium compared to normoxia (Fig. 2g). In fact, 13 C-aspartate was the only 13 C-…
ischaemic myocardium compared to normoxia (Fig. 2g). In fact, 13 C-aspartate was the only 13 C-…
[PDF][PDF] Succinate dehydrogenase supports metabolic repurposing of mitochondria to drive inflammatory macrophages
Activated macrophages undergo metabolic reprogramming, which drives their pro-inflammatory
phenotype, but the mechanistic basis for this remains obscure. Here, we demonstrate …
phenotype, but the mechanistic basis for this remains obscure. Here, we demonstrate …
Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1
The endogenous metabolite itaconate has recently emerged as a regulator of macrophage
function, but its precise mechanism of action remains poorly understood 1 , 2 , 3 . Here we …
function, but its precise mechanism of action remains poorly understood 1 , 2 , 3 . Here we …
[HTML][HTML] OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion
C Frezza, S Cipolat, OM De Brito, M Micaroni… - Cell, 2006 - cell.com
… effects on cytochrome c release and mitochondria depolarization (Figures 2C and 2D).
These results indicate that functional OPA1 decreases release of cytochrome c and loss of …
These results indicate that functional OPA1 decreases release of cytochrome c and loss of …
[HTML][HTML] Mitochondrial cristae shape determines respiratory chain supercomplexes assembly and respiratory efficiency
S Cogliati, C Frezza, ME Soriano, T Varanita… - Cell, 2013 - cell.com
Respiratory chain complexes assemble into functional quaternary structures called
supercomplexes (RCS) within the folds of the inner mitochondrial membrane, or cristae. Here, we …
supercomplexes (RCS) within the folds of the inner mitochondrial membrane, or cristae. Here, we …
Organelle isolation: functional mitochondria from mouse liver, muscle and cultured filroblasts
C Frezza, S Cipolat, L Scorrano - Nature protocols, 2007 - nature.com
… that they amplify apoptosis by releasing cytochrome c and other intermembrane space proteins
… , the precise mechanism by which cytochrome c is released remains a matter of intense …
… , the precise mechanism by which cytochrome c is released remains a matter of intense …