… resides on the pyrimidine C-2 substituent ring, the pyrimidine 4-substituent is C-linked and
… of acquired resistance to AZD9291 (C. Eberlein and colleagues; manuscript in preparation). …

Bacteria have evolved an array of adaptive mechanisms enabling them to survive and grow
in the presence of different environmental stresses. These mechanisms include either …

Plastics are extremely useful materials that have transformed our society in a myriad of ways.
However, the widespread use of these materials has led to a staggering amount of plastic …

Biotechnological production in bacteria enables access to numerous valuable chemical
compounds. Nowadays, advanced molecular genetic toolsets, enzyme engineering as well as …

CXCR2 has been suggested to have both tumor-promoting and tumor-suppressive
properties. Here we show that CXCR2 signaling is upregulated in human pancreatic cancer, …

Sonoluminescence is explained in terms of quantum vacuum radiation by moving interfaces
between media of different polarizability. It can be considered as a dynamic Casimir effect, …

Resistance to targeted EGFR inhibitors is likely to develop in EGFR-mutant lung cancers.
Early identification of innate or acquired resistance mechanisms to these agents is essential to …

A novel series of small-molecule inhibitors has been developed to target the double mutant
form of the epidermal growth factor receptor (EGFR) tyrosine kinase, which is resistant to …

… The force on a stationary dielectric is determined in Appendix C. … and c are set equal to 1
unless explicitly indicated. All special functions are defined as … C. Agenda and open questions …

Hybridization is recognized as a powerful mechanism of speciation and a driving force in
generating biodiversity. However, only few multicellular species, limited to a handful of plants …