User profiles for C. Dessimoz

Christophe Dessimoz

Professor at UNIL and Director of SIB Swiss Institute of Bioinformatics
Verified email at unil.ch
Cited by 16035

[HTML][HTML] Structural variant calling: the long and the short of it

…, N Gobet, DI Cruz-Dávalos, N Mounier, C Dessimoz… - Genome biology, 2019 - Springer
… Another technology relying on short-read sequencing is Hi-C, which is used to identify
regions that are in close proximity in 3D space, which provides longer-range information than …

Base-calling for next-generation sequencing platforms

C Ledergerber, C Dessimoz - Briefings in bioinformatics, 2011 - academic.oup.com
… Shown is the projection of measured intensities of the first sequencing cycle of the phiX174
data onto the axes corresponding to A and C. τ: In past chemistries the T-fluophore was not …

The what, where, how and why of gene ontology—a primer for bioinformaticians

…, N Škunca, C Dessimoz - Briefings in bioinformatics, 2011 - academic.oup.com
… Inferences can be made by following simple rules, for example, if A ‘is_a’ B and B is ‘part_of”
C then A is also ‘part_of” C. In this way relations that are not immediately obvious, but …

Towards practical, high-capacity, low-maintenance information storage in synthesized DNA

N Goldman, P Bertone, S Chen, C Dessimoz… - nature, 2013 - nature.com
… This in turn was converted in silico to our DNA code (c, green) by replacement of each trit
with one of the three nucleotides different from the previous one used, ensuring no …

[HTML][HTML] GOATOOLS: A Python library for Gene Ontology analyses

…, O Botvinnik, M Weigel, W Dampier, C Dessimoz… - Scientific reports, 2018 - nature.com
The biological interpretation of gene lists with interesting shared properties, such as up-or
down-regulation in a particular experiment, is typically accomplished using gene ontology …

Survey of branch support methods demonstrates accuracy, power, and robustness of fast likelihood-based approximation schemes

M Anisimova, M Gil, JF Dufayard, C Dessimoz… - Systematic …, 2011 - academic.oup.com
… , the log-likelihood ℓ C for configuration C is a sum of site log … ℓ C * for configuration C
may be quickly computed by summing up the original site log likelihoods for configuration C

[HTML][HTML] Approximate bayesian computation

…, J Corander, M Foll, C Dessimoz - PLoS computational …, 2013 - journals.plos.org
Approximate Bayesian computation (ABC) constitutes a class of computational methods
rooted in Bayesian statistics . In all model-based statistical inference , the likelihood function is …

[HTML][HTML] Transient structural variations have strong effects on quantitative traits and reproductive isolation in fission yeast

…, L Shaw, C Rallis, F Balloux, C Dessimoz… - Nature …, 2017 - nature.com
Large structural variations (SVs) within genomes are more challenging to identify than smaller
genetic variants but may substantially contribute to phenotypic diversity and evolution. We …

[HTML][HTML] An expanded evaluation of protein function prediction methods shows an improvement in accuracy

…, Z Zhong, J Cheng, A Altenhoff, N Skunca, C Dessimoz… - Genome biology, 2016 - Springer
Background A major bottleneck in our understanding of the molecular underpinnings of life
is the assignment of function to proteins. While molecular experiments provide the most …

[HTML][HTML] The CAFA challenge reports improved protein function prediction and new functional annotations for hundreds of genes through experimental screens

…, PH Chi, WC Tseng, M Linial, PW Rose, C Dessimoz… - Genome biology, 2019 - Springer
Background The Critical Assessment of Functional Annotation (CAFA) is an ongoing, global,
community-driven effort to evaluate and improve the computational annotation of protein …