All cancers are caused by somatic mutations; however, understanding of the biological
processes generating these mutations is limited. The catalogue of somatic mutations from a …

Roughly 50% of cancer cases occur in people aged 65 years or older. Older people are often
diagnosed at a later stage and might receive less (intensive) treatment, which might affect …

We analysed whole-genome sequences of 560 breast cancers to advance understanding of
the driver mutations conferring clonal advantage and the mutational processes generating …

All cancers carry somatic mutations in their genomes. A subset, known as driver mutations,
confer clonal selective advantage on cancer cells and are causally implicated in oncogenesis …

Background We have previously shown the prognostic importance of tumor-infiltrating
lymphocytes (TILs) in newly diagnosed triple-negative breast cancer (TNBC) using tumor samples …

… C ) Analysis of the whole dataset of 572 patients by GG. GG1 = green ; GG3 = red . All … C
) Analysis of the whole dataset of 572 patients by GG. GG1 = green ; GG3 = red . All statistical …

… b, c Higher magnification of the tumour–liver interface of CRC liver metastases with a
desmoplastic HGP. The blue double-headed arrow indicates the desmoplastic rim that separates …

Background Invasive lobular breast cancer (ILC) is the second most common type of breast
cancer after invasive breast cancer of no special type (NST), representing up to 15% of all …

CD4 + T cells are critical regulators of immune responses, but their functional role in human
breast cancer is relatively unknown. The goal of this study was to produce an image of CD4 …

… Up to five subclasses of BCs (basal-like, ErbB2-like, and luminal A, B, and C) have been
proposed based on an intrinsic gene set, with the basal-like subtype, which was mainly estro…