Introduction We performed a systematic review and meta-analysis of the Alzheimer's disease
(AD) literature to examine consistency of functional connectivity alterations in AD dementia …

Background In X-linked adrenoleukodystrophy, mutations in ABCD1 lead to loss of function
of the ALD protein. Cerebral adrenoleukodystrophy is characterized by demyelination and …

Background Sickle cell disease is characterized by hemolytic anemia, pain, and progressive
organ damage. A high level of erythrocyte fetal hemoglobin (HbF) comprising α- and γ-…

Importance National Institute on Aging–Alzheimer’s Association (NIA-AA) workgroups have
proposed biological research criteria intended to identify individuals with preclinical …

… To quantify the severity of inter-site effects, we derived Cohen's d effect size measure for
each connection: | β c | / σ ^ , with β c being the weight associated with the contrast. The …

… The left side of part C represents connectivity between the regions of interest and the rest
of the brain; the right side of part C represents connectivity between the regions of interest. …

… Dansereau has previously served on advisory committees for Bluebird Bio and Novartis
Pharmaceuticals. The article has been reviewed by independent peer reviewers to ensure that it …

… The hyperparameter C of the SVM was optimized using nested cross-validation. Each
model used the residuals from a regression of confounding variables (gender, age and motion …

Background Major prevention trials for Alzheimer’s disease (AD) are now focusing on multidomain
lifestyle interventions. However, the exact combination of behavioral factors related to …

Importance Preventive trials of anti-amyloid agents might preferably recruit persons showing
earliest biologically relevant β-amyloid (Aβ) binding on positron emission tomography (PET)…