A review of select human-building interfaces and their relationship to human behavior, energy use and occupant comfort
…, C McIlvennie, C Brackley, M Tarantini, C Piselli… - Building and …, 2020 - Elsevier
… It is also recommended that users have ±2 C of control with increments of 1 C, and that the
system responds quickly to adjustments of the setpoint. Developing interfaces with the user in …
system responds quickly to adjustments of the setpoint. Developing interfaces with the user in …
Nonspecific bridging-induced attraction drives clustering of DNA-binding proteins and genome organization
… (C) The fraction of beads in clusters increases with time only if there is an attraction (two …
(C) Both the fraction of beads in clusters and average cluster size increase with time (two …
(C) Both the fraction of beads in clusters and average cluster size increase with time (two …
[PDF][PDF] HMGB2 loss upon senescence entry disrupts genomic organization and induces CTCF clustering across cell types
…, CA Brackley, H Gothe, O Drechsel, C Becker… - Molecular cell, 2018 - cell.com
… This is now feasible due to the advent of Hi-C technology that captures spatial interactions
within and between chromosomes (Belton et al., 2012). As a result of Hi-C studies, we now …
within and between chromosomes (Belton et al., 2012). As a result of Hi-C studies, we now …
Ten questions concerning occupant-centric control and operations
… It was found that there was an average spatial temperature variation of approximately 2 C
with a standard deviation of 1.2 C across the homes studied. Given that indoor temperature is …
with a standard deviation of 1.2 C across the homes studied. Given that indoor temperature is …
Simulated binding of transcription factors to active and inactive regions folds human chromosomes into loops, rosettes and topological domains
CA Brackley, J Johnson, S Kelly, PR Cook… - Nucleic acids …, 2016 - academic.oup.com
… However, it works less well with sparser data from simulations in the next Section and Hi-C
data, where the ‘difference’ plot gives better results (so we use it in what follows, aided by …
data, where the ‘difference’ plot gives better results (so we use it in what follows, aided by …
[PDF][PDF] Polymer simulations of heteromorphic chromatin predict the 3D folding of complex genomic loci
… -C profiles (Figure S4A); loosely this can be interpreted as the proportion of Capture-C …
Although we noted very little visible change in the simulated Capture-C profiles, the Q-score …
Although we noted very little visible change in the simulated Capture-C profiles, the Q-score …
Nonequilibrium chromosome looping via molecular slip links
We propose a model for the formation of chromatin loops based on the diffusive sliding of
molecular slip links. These mimic the behavior of molecules like cohesin, which, along with the …
molecular slip links. These mimic the behavior of molecules like cohesin, which, along with the …
[HTML][HTML] Predicting the three-dimensional folding of cis-regulatory regions in mammalian genomes using bioinformatic data and polymer models
… can be probed using methods like Capture-C. However, it is unclear how such population-…
To test the model, we perform FISH experiments and compare with Capture-C data. Starting …
To test the model, we perform FISH experiments and compare with Capture-C data. Starting …
Predicting genome organisation and function with mechanistic modelling
… (B,C) Two prevalent approaches that use CG models to understand 3D genome folding are
inverse modelling and mechanistic modelling. (B) In the inverse approach, 3C-based data …
inverse modelling and mechanistic modelling. (B) In the inverse approach, 3C-based data …
[PDF][PDF] Ephemeral protein binding to DNA shapes stable nuclear bodies and chromatin domains
… 1, Mr and MF are the chromatin and protein mobility, respectively, so that Mra1hD1 and
MFa2hD2 represent effective diffusion coefficients, while c is the coefficient describing bridging …
MFa2hD2 represent effective diffusion coefficients, while c is the coefficient describing bridging …