In 1991, a group of expert scientists at a Wingspread work session on endocrine-disrupting
chemicals (EDCs) concluded that “Many compounds introduced into the environment by …

Background: Diabetes is a major threat to public health in the United States and worldwide.
Understanding the role of environmental chemicals in the development or progression of …

… of the malignant gliomas and glial cell hyperplasias are presented in Appendix C. … in
Appendix D, applying the diagnostic criteria established during the PWGs outlined in Appendix C. …

… The vehicle control, laboratory-grade corn oil (CAS 8001-30-7, Cat# C-8627), and the
phthalates used in this study were purchased from Sigma-Aldrich (St Louis, MO): BBP (CAS 85-68-…

Triazole fungicides associated with a range of reported male reproductive effects in experimental
animals were selected to assess potential toxic modes of action. Wistar Han rats were …

Scientists have identified environmental chemicals that display anti‐androgenic activity via
multiple mechanisms of action. Early studies focused on pesticides acting as androgen …

Four triazole fungicides were studied using toxicogenomic techniques to identify potential
mechanisms of action. Adult male Sprague-Dawley rats were dosed for 14 days by gavage …

In November, 2023, a Working Group of 30 scientists from 11 countries met at the International
Agency for Research on Cancer (IARC) in Lyon, France, to finalise their evaluation of the …

Deriving No Observed Adverse Effect Level (NOAEL) or benchmark dose is important for risk
assessment and can be influenced by study design considerations. In order to define the di-…

… Plasma was separated by centrifugation at 1750 xg for 10 min at 4 C and stored at -20 C. In
specific gavage dose groups (20 mg/kg for KPFBS; 16 mg/kg for PFHxSKlt; 2 mg/kg, 20 mg/kg…