The hallmark of type 1 diabetes is specific destruction of pancreatic islet β-cells. Apoptosis
of β-cells may be crucial at several points during disease progression, initiating leukocyte …

… of a battery of PTA gene transcripts (eg, encoding insulin, salivary protein 1, and fatty acid–binding
protein); interestingly, there were also a number of PTA transcripts (eg, encoding C-…

Regulatory T cells (T reg cells) characterized by expression of the transcription factor Foxp3
play a key role in immune homeostasis. Rather than a monomorphic population strictly …

10.7554/eLife.27041.001 The recent advent of methods for high-throughput single-cell
molecular profiling has catalyzed a growing sense in the scientific community that the time is ripe …

Euclid is a space-based survey mission from the European Space Agency designed to
understand the origin of the Universe's accelerating expansion. It will use cosmological probes to …

Abstract The Immunological Genome Project combines immunology and computational
biology laboratories in an effort to establish a complete'road map'of gene-expression and …

… 1C). Autoantibodies had the same kind of target distribution. Multiple organs were targeted,
… (C) Salivary gland infiltrates and retinal degeneration develop in a time-dependent manner. …

Antigen stimulation of immune cells activates the transcription factor NFAT, a key regulator
of T cell activation and anergy. NFAT forms cooperative complexes with the AP-1 family of …

… directly comparing T conv cells (c) in fat versus spleen (left), fat versus lymph node (center)
or lymph node versus spleen (right). The numbers in b and c indicate the number of genes …

Gut microbial induction of host immune maturation exemplifies host-microbe mutualism. We
colonized germ-free (GF) mice with mouse microbiota (MMb) or human microbiota (HMb) to …