Silencing chromatin: comparing modes and mechanisms
C Beisel, R Paro - Nature Reviews Genetics, 2011 - nature.com
Recent transcriptome analyses show that substantial proportions of eukaryotic genomes
can be copied into RNAs, many of which do not encode protein sequences. However, cells …
can be copied into RNAs, many of which do not encode protein sequences. However, cells …
[HTML][HTML] CRISPR technologies and the search for the PAM-free nuclease
D Collias, CL Beisel - Nature communications, 2021 - nature.com
The ever-expanding set of CRISPR technologies and their programmable RNA-guided
nucleases exhibit remarkable flexibility in DNA targeting. However, this flexibility comes with an …
nucleases exhibit remarkable flexibility in DNA targeting. However, this flexibility comes with an …
Base pairing small RNAs and their roles in global regulatory networks
… as C. Regulator A controls the expression of genes B and C, and regulator B controls the
expression of gene C… Thus, regulator A directly and indirectly controls the expression of gene C. …
expression of gene C… Thus, regulator A directly and indirectly controls the expression of gene C. …
[HTML][HTML] A vaccine to prevent herpes zoster and postherpetic neuralgia in older adults
…, JH Zhang, PN Peduzzi, CE Beisel… - … England Journal of …, 2005 - Mass Medical Soc
Background The incidence and severity of herpes zoster and postherpetic neuralgia increase
with age in association with a progressive decline in cell-mediated immunity to varicella–…
with age in association with a progressive decline in cell-mediated immunity to varicella–…
Neutrophils escort circulating tumour cells to enable cell cycle progression
…, C Donato, R Scherrer, J Singer, C Beisel, C Kurzeder… - Nature, 2019 - nature.com
A better understanding of the features that define the interaction between cancer cells and
immune cells is important for the development of new cancer therapies 1 . However, focus is …
immune cells is important for the development of new cancer therapies 1 . However, focus is …
[PDF][PDF] An immune atlas of clear cell renal cell carcinoma
Immune cells in the tumor microenvironment modulate cancer progression and are attractive
therapeutic targets. Macrophages and T cells are key components of the microenvironment, …
therapeutic targets. Macrophages and T cells are key components of the microenvironment, …
[PDF][PDF] Circulating tumor cell clustering shapes DNA methylation to enable metastasis seeding
…, C Beisel, CU Stirnimann, C Kurzeder… - Cell, 2019 - cell.com
The ability of circulating tumor cells (CTCs) to form clusters has been linked to increased
metastatic potential. Yet biological features and vulnerabilities of CTC clusters remain largely …
metastatic potential. Yet biological features and vulnerabilities of CTC clusters remain largely …
Repressive and active histone methylation mark distinct promoters in human and mouse spermatozoa
…, L Ramos, EJ Oakeley, TC Roloff, C Beisel… - Nature structural & …, 2010 - nature.com
In higher eukaryotes, histone methylation is involved in maintaining cellular identity during
somatic development. As most nucleosomes are replaced by protamines during …
somatic development. As most nucleosomes are replaced by protamines during …
Clonal evolution and clinical correlates of somatic mutations in myeloproliferative neoplasms
Myeloproliferative neoplasms (MPNs) are a group of clonal disorders characterized by aberrant
hematopoietic proliferation and an increased tendency toward leukemic transformation. …
hematopoietic proliferation and an increased tendency toward leukemic transformation. …
Self‐assembled DNA nanoclews for the efficient delivery of CRISPR–Cas9 for genome editing
CRISPR–Cas9 represents a promising platform for genome editing, yet means for its safe
and efficient delivery remain to be fully realized. A novel vehicle that simultaneously delivers …
and efficient delivery remain to be fully realized. A novel vehicle that simultaneously delivers …