Effects of school-based multicomponent positive psychology interventions on well-being and distress in adolescents: A systematic review and meta-analysis
Multicomponent positive psychology interventions are increasing in the general population
but the study of its effectiveness in adolescents is still scarce, especially in the school context. …
but the study of its effectiveness in adolescents is still scarce, especially in the school context. …
Molecular approaches to treatment of hepatocellular carcinoma
A Lachenmayer, C Alsinet, CY Chang… - Digestive and Liver …, 2010 - Elsevier
… HGF overexpression and aberrant c-Met activation has been reported in HCC due to c-Met …
C-Met expression showed an inverse correlation to patient survival and c-Met silencing led to …
C-Met expression showed an inverse correlation to patient survival and c-Met silencing led to …
New strategies in hepatocellular carcinoma: genomic prognostic markers
… Most HCCs arise within a previously damaged liver; chronic hepatitis (B and C) and
alcohol abuse being the leading environmental causes for the underlying liver disease (1). …
alcohol abuse being the leading environmental causes for the underlying liver disease (1). …
Focal Gains of VEGFA and Molecular Classification of Hepatocellular Carcinoma
…, DJ Donovan, SN Thung, M Sole, V Tovar, C Alsinet… - Cancer research, 2008 - AACR
Hepatocellular carcinomas represent the third leading cause of cancer-related deaths
worldwide. The vast majority of cases arise in the context of chronic liver injury due to hepatitis B …
worldwide. The vast majority of cases arise in the context of chronic liver injury due to hepatitis B …
Pivotal role of mTOR signaling in hepatocellular carcinoma
… We used a c-fos luciferase reporter as a surrogate of EGF signaling activation, and found
a significant decrease in luciferase activity of up to 65% in Huh-7 cells treated with EGFR …
a significant decrease in luciferase activity of up to 65% in Huh-7 cells treated with EGFR …
Integrative molecular analysis of intrahepatic cholangiocarcinoma reveals 2 classes that have different outcomes
…, C Alsinet, H Cornella, B Klotzle, JB Fan, C Cotsoglou… - Gastroenterology, 2013 - Elsevier
… Tumors in this class were enriched for nuclear pSTAT3 (77% vs 58% in the proliferation
class; P = .02; Figure 2C). Immunostaining against the active subunit of nuclear factor-κB …
class; P = .02; Figure 2C). Immunostaining against the active subunit of nuclear factor-κB …
Combining clinical, pathology, and gene expression data to predict recurrence of hepatocellular carcinoma
Background & Aims In approximately 70% of patients with hepatocellular carcinoma (HCC)
treated by resection or ablation, disease recurs within 5 years. Although gene expression …
treated by resection or ablation, disease recurs within 5 years. Although gene expression …
Predicting the mutations generated by repair of Cas9-induced double-strand breaks
… We also observed that sequences with low G+C fraction were not as frequently used as … C
for 30 s, 24 cycles of 98 C for 10 s, 61 C for 15 s and 72 C for 20 s, and the final extension 72 C …
for 30 s, 24 cycles of 98 C for 10 s, 61 C for 15 s and 72 C for 20 s, and the final extension 72 C …
[PDF][PDF] UHRF1 overexpression drives DNA hypomethylation and hepatocellular carcinoma
…, RT Bronson, A Lachenmayer, K Revill, C Alsinet… - Cancer cell, 2014 - cell.com
Ubiquitin-like with PHD and RING finger domains 1 (UHRF1) is an essential regulator of DNA
methylation that is highly expressed in many cancers. Here, we use transgenic zebrafish, …
methylation that is highly expressed in many cancers. Here, we use transgenic zebrafish, …
Wnt-pathway activation in two molecular classes of hepatocellular carcinoma and experimental modulation by sorafenib
A Lachenmayer, C Alsinet, R Savic, L Cabellos… - Clinical cancer …, 2012 - AACR
Purpose: Hepatocellular carcinoma (HCC) is a heterogeneous cancer with active Wnt
signaling. Underlying biologic mechanisms remain unclear and no drug targeting this pathway …
signaling. Underlying biologic mechanisms remain unclear and no drug targeting this pathway …