Novel coronavirus (COVID-19 or 2019-nCoV or SARS-CoV-2), which suddenly emerged in
December 2019 is still haunting the entire human race and has affected not only the …

Background Recent developments in deep (next-generation) sequencing technologies are
significantly impacting medical research. The global analysis of protein coding regions in …

Purpose: Cyclin-dependent kinase 9 (CDK9) is a transcriptional regulator and potential
therapeutic target for many cancers. Multiple nonselective CDK9 inhibitors have progressed …

BET bromodomain inhibitors (BBDIs) are candidate therapeutic agents for triple-negative
breast cancer (TNBC) and other cancer types, but inherent and acquired resistance to BBDIs …

Using genome-wide clustered regularly interspaced short palindromic repeats (CRISPR)
screens to understand endocrine drug resistance, we discovered ARID1A and other SWI/SNF …

Current evidence suggests that plasma cell-free DNA (cfDNA) is fragmented around a mode
of 166 bp. Data supporting this view has been mainly acquired through the analysis of …

Surfaces produced by machining processes such as grinding, shaping and turning and some
magnetic disk texturing processes such as sputtering and laser processing are frequently …

Understanding the dynamics of endogenous protein–protein interactions in complex networks
is pivotal in deciphering disease mechanisms. To enable the in-depth analysis of protein …

The intestinal epithelium is largely maintained by self-renewing stem cells but with apparently
committed progenitors also contributing, particularly following tissue damage. However, …

Ependymomas are hard-to-treat brain tumors driven by translocations between ZFTA and a
variety of transcriptional coactivators. We dissect the transforming mechanism of these fusion …