Alpha-cardiac actin mutations produce atrial septal defects

H Matsson, J Eason, CS Bookwalter… - Human molecular …, 2008 - academic.oup.com
Atrial septal defect (ASD) is one of the most frequent congenital heart defects (CHDs) with a
variable phenotypic effect depending on the size of the septal shunt. We identified two …

Myosin V and Kinesin act as tethers to enhance each others' processivity

MY Ali, H Lu, CS Bookwalter… - Proceedings of the …, 2008 - National Acad Sciences
Organelle transport to the periphery of the cell involves coordinated transport between the
processive motors kinesin and myosin V. Long-range transport takes place on microtubule …

Recruitment of two dyneins to an mRNA-dependent Bicaudal D transport complex

TE Sladewski, N Billington, MY Ali, CS Bookwalter… - Elife, 2018 - elifesciences.org
10.7554/eLife.36306.001 We investigated the role of full-length Drosophila Bicaudal D (BicD)
binding partners in dynein-dynactin activation for mRNA transport on microtubules. Full-…

[HTML][HTML] MAP7 regulates organelle transport by recruiting kinesin-1 to microtubules

…, H Lu, EB Krementsova, CS Bookwalter… - Journal of Biological …, 2019 - ASBMB
Microtubule-associated proteins (MAPs) regulate microtubule polymerization, dynamics, and
organization. In addition, MAPs alter the motility of kinesin and dynein to control trafficking …

[HTML][HTML] Plasmodium myosin A drives parasite invasion by an atypical force generating mechanism

…, D Auguin, TCA Blake, CS Bookwalter… - Nature …, 2019 - nature.com
Plasmodium parasites are obligate intracellular protozoa and causative agents of malaria,
responsible for half a million deaths each year. The lifecycle progression of the parasite is …

Vascular disease-causing mutation R258C in ACTA2 disrupts actin dynamics and interaction with myosin

H Lu, PM Fagnant, CS Bookwalter… - Proceedings of the …, 2015 - National Acad Sciences
Point mutations in vascular smooth muscle α-actin (SM α-actin), encoded by the gene
ACTA2, are the most prevalent cause of familial thoracic aortic aneurysms and dissections (TAAD). …

[HTML][HTML] Functional consequences of a mutation in an expressed human α-cardiac actin at a site implicated in familial hypertrophic cardiomyopathy

CS Bookwalter, KM Trybus - Journal of Biological Chemistry, 2006 - ASBMB
Point mutations in human α-cardiac actin cause familial hypertrophic cardiomyopathy.
Functional characterization of these actin mutants has been limited by the lack of a high level …

[HTML][HTML] A Toxoplasma gondii class XIV myosin, expressed in Sf9 cells with a parasite co-chaperone, requires two light chains for fast motility

CS Bookwalter, A Kelsen, JM Leung, GE Ward… - Journal of Biological …, 2014 - ASBMB
Many diverse myosin classes can be expressed using the baculovirus/Sf9 insect cell
expression system, whereas others have been recalcitrant. We hypothesized that most myosins …

[HTML][HTML] Motor domain phosphorylation modulates kinesin-1 transport

…, J Sheung, AR Thompson, CS Bookwalter… - Journal of Biological …, 2013 - ASBMB
Disruptions in microtubule motor transport are associated with a variety of neurodegenerative
diseases. Post-translational modification of the cargo-binding domain of the light and …

Human actin mutations associated with hypertrophic and dilated cardiomyopathies demonstrate distinct thin filament regulatory properties in vitro

EP Debold, W Saber, Y Cheema, CS Bookwalter… - Journal of molecular and …, 2010 - Elsevier
Two cardiomyopathic mutations were expressed in human cardiac actin, using a Baculovirus/insect
cell system; E99K is associated with hypertrophic cardiomyopathy whereas R312H …