Protein interactions regulate the systems-level behavior of cells; thus, deciphering the structure
and dynamics of protein interaction networks in their cellular context is a central goal in …

The mutation process ultimately defines the genetic features of all populations and, hence,
has a bearing on a wide range of issues involving evolutionary genetics, inheritance, and …

Identifying the properties of gene networks that influence their evolution is a fundamental
research goal. However, modes of evolution cannot be inferred solely from the distribution of …

Previous studies in Saccharomyces cerevisiae have demonstrated that cryptic promoters
within coding regions activate transcription in particular mutants. We have performed a …

Owing to their crucial roles in regulating protein function, phosphorylation sites (phosphosites)
are expected to be evolutionarily conserved. However, mixed results regarding this …

Hybrids between species are often characterized by novel gene-expression patterns. A
recent study on allele-specific gene expression in hybrids between species of Drosophila …

The G protein-coupled receptor (GPCR) superfamily represents the most important class of
pharmaceutical targets. Therefore, the characterization of receptor cascades and their …

Hybridization is recognized as a powerful mechanism of speciation and a driving force in
generating biodiversity. However, only few multicellular species, limited to a handful of plants …

Saccharomyces cerevisiae, the budding yeast, is the most thoroughly studied eukaryote at
the cellular, molecular, and genetic levels. Yet, until recently, we knew very little about its …

In interspecific hybrids, novel phenotypes often emerge from the interaction of two divergent
genomes. Interactions between the two transcriptional networks are assumed to contribute …