… Drummond, DA & Wilke, CO Mistranslation-induced protein misfolding as a dominant
constraint on coding-sequence evolution. Cell 134, 341–352 (2008). A bioinformatics and …

It has long been recognized that certain sites within a protein, such as sites in the protein
core or catalytic residues in enzymes, are evolutionarily more conserved than other sites. …

Strikingly consistent correlations between rates of coding-sequence evolution and gene
expression levels are apparent across taxa, but the biological causes behind the selective …

Much recent work has explored molecular and population-genetic constraints on the rate of
protein sequence evolution. The best predictor of evolutionary rate is expression level, for …

For decades, rates of protein evolution have been interpreted in terms of the vague concept
of functional importance. Slowly evolving proteins or sites within proteins were assumed to …

Darwinian evolution favours genotypes with high replication rates, a process called ‘survival
of the fittest’. However, knowing the replication rate of each individual genotype may not …

Avida is a software platform for experiments with self-replicating and evolving computer
programs. It provides detailed control over experimental settings and protocols, a large array of …

To determine whether genes retain ancestral functions over a billion years of evolution and
to identify principles of deep evolutionary divergence, we replaced 414 essential yeast …

Antiretroviral therapy can reduce human immunodeficiency virus type 1 (HIV-1) viremia to
below the detection limit of ultrasensitive clinical assays (50 copies of HIV-1 RNA/ml). However…

A gene's rate of sequence evolution is among the most fundamental evolutionary quantities
in common use, but what determines evolutionary rates has remained unclear. Here, we …