To elucidate the role of Tau isoforms and post-translational modification (PTM) stoichiometry
in Alzheimer's disease (AD), we generated a high-resolution quantitative proteomics map of …

Background Mouse models that overexpress human mutant Tau (P301S and P301L) are
commonly used in preclinical studies of Alzheimer’s Disease (AD) and while several drugs …

Characterizing perturbation of molecular pathways in congenital Zika virus (ZIKV) infection
is critical for improved therapeutic approaches. Leveraging integrative systems biology, …

Combining robust proteomics instrumentation with high-throughput enabling liquid
chromatography (LC) systems (eg, timsTOF Pro and the Evosep One system, respectively) enabled …

Aggregation prone molecules, such as tau, form both historically well characterized fibrillar
deposits (neurofibrillary tangles) and recently identified phosphate-buffered saline (PBS) …

Current tools for visualization and integration of proteomics with other omics datasets are
inadequate for large-scale studies and capture only basic sequence identity information. …

Objectives Total pancreatectomy with islet autotransplantation (TPIAT) is a surgical option for
refractory chronic pancreatitis-related pain. Despite the known clinical implications of TPIAT…

In liquid-chromatography–tandem-mass-spectrometry-based proteomics, information about
the presence and stoichiometry of protein modifications is not readily available. To overcome …

Improvements in LC-MS/MS methods and technology have enabled the identification of
thousands of modified peptides in a single experiment. However, protein regulation by post-…

Motivation: Accurate quantitative information about the protein abundance is crucial for
understanding a biological system and its dynamics. Protein abundance is commonly estimated …