Mammalian females have two X chromosomes and males have only one. This has led to
the evolution of special mechanisms of dosage compensation. The inactivation of one X …

To achieve a balanced gene expression dosage between males (XY) and females (XX),
mammals have evolved a compensatory mechanism to randomly inactivate one of the female X …

Genes on the mammalian X chromosome are present in one copy in males and two copies
in females. The complex mechanisms that regulate the X chromosome lead to evolutionary …

The organophosphate cholinesterase inhibitor paraoxon is hydrolysed by serum
paraoxonase/arylesterase. A genetic polymorphism of paraoxonase (PON) activity which determines …

The ligand for CD40 (CD40L) is a membrane glycoprotein on activated T cells that induces
B cell proliferation and immunoglobulin secretion. Abnormalities in the CD40L gene were …

Hereditary neuropathy with liability to pressure palsies (HNPP) is an autosomal dominant
disorder that causes episodes of focal demyelinating neuropathy following minor trauma to …

We applied a combinatorial indexing assay, sci-ATAC-seq, to profile genome-wide chromatin
accessibility in ∼100,000 single cells from 13 adult mouse tissues. We identify 85 distinct …

Cohesin is required to prevent premature dissociation of sister chromatids after DNA replication.
Although its role in chromatid cohesion is well established, the functional significance of …

Monosomy of the X chromosome owing to divergence between the sex chromosomes leads
to dosage compensation mechanisms to restore balanced expression between the X and …

We present single-cell combinatorial indexed Hi-C (sciHi-C), a method that applies
combinatorial cellular indexing to chromosome conformation capture. In this proof of concept, we …