User profiles for C. L. Myers
Chad MyersUniversity of Minnesota Verified email at umn.edu Cited by 17264 |
The genetic landscape of a cell
A genome-scale genetic interaction map was constructed by examining 5.4 million gene-gene
pairs for synthetic genetic interactions, generating quantitative genetic interaction profiles …
pairs for synthetic genetic interactions, generating quantitative genetic interaction profiles …
A global genetic interaction network maps a wiring diagram of cellular function
INTRODUCTION Genetic interactions occur when mutations in two or more genes combine
to generate an unexpected phenotype. An extreme negative or synthetic lethal genetic …
to generate an unexpected phenotype. An extreme negative or synthetic lethal genetic …
[HTML][HTML] Als3 is a Candida albicans invasin that binds to cadherins and induces endocytosis by host cells
QT Phan, CL Myers, Y Fu, DC Sheppard… - PLoS …, 2007 - journals.plos.org
Candida albicans is the most common cause of hematogenously disseminated and oropharyngeal
candidiasis. Both of these diseases are characterized by fungal invasion of host cells. …
candidiasis. Both of these diseases are characterized by fungal invasion of host cells. …
Evaluation and design of genome-wide CRISPR/SpCas9 knockout screens
The adaptation of CRISPR/SpCas9 technology to mammalian cell lines is transforming the
study of human functional genomics. Pooled libraries of CRISPR guide RNAs (gRNAs) …
study of human functional genomics. Pooled libraries of CRISPR guide RNAs (gRNAs) …
Systematic exploration of essential yeast gene function with temperature-sensitive mutants
Conditional temperature-sensitive (ts) mutations are valuable reagents for studying essential
genes in the yeast Saccharomyces cerevisiae. We constructed 787 ts strains, covering 497 (…
genes in the yeast Saccharomyces cerevisiae. We constructed 787 ts strains, covering 497 (…
Quantitative analysis of fitness and genetic interactions in yeast on a genome scale
Global quantitative analysis of genetic interactions is a powerful approach for deciphering
the roles of genes and mapping functional relationships among pathways. Using colony size …
the roles of genes and mapping functional relationships among pathways. Using colony size …
[HTML][HTML] Comprehensive curation and analysis of global interaction networks in Saccharomyces cerevisiae
Background The study of complex biological networks and prediction of gene function has
been enabled by high-throughput (HTP) methods for detection of genetic and protein …
been enabled by high-throughput (HTP) methods for detection of genetic and protein …
Systematic exploration of synergistic drug pairs
Drug synergy allows a therapeutic effect to be achieved with lower doses of component
drugs. Drug synergy can result when drugs target the products of genes that act in parallel …
drugs. Drug synergy can result when drugs target the products of genes that act in parallel …
Exploring the functional landscape of gene expression: directed search of large microarray compendia
Motivation: The increasing availability of gene expression microarray technology has
resulted in the publication of thousands of microarray gene expression datasets investigating …
resulted in the publication of thousands of microarray gene expression datasets investigating …
[HTML][HTML] A critical assessment of Mus musculusgene function prediction using integrated genomic evidence
Background: Several years after sequencing the human genome and the mouse genome,
much remains to be discovered about the functions of most human and mouse genes. …
much remains to be discovered about the functions of most human and mouse genes. …