User profiles for C. L. Myers

Chad Myers

University of Minnesota
Verified email at umn.edu
Cited by 17264

The genetic landscape of a cell

…, AC Gingras, QD Morris, PM Kim, CA Kaiser, CL Myers… - science, 2010 - science.org
A genome-scale genetic interaction map was constructed by examining 5.4 million gene-gene
pairs for synthetic genetic interactions, generating quantitative genetic interaction profiles …

A global genetic interaction network maps a wiring diagram of cellular function

…, CL Moore, AP Rosebrock, AA Caudy, CL Myers… - Science, 2016 - science.org
INTRODUCTION Genetic interactions occur when mutations in two or more genes combine
to generate an unexpected phenotype. An extreme negative or synthetic lethal genetic …

[HTML][HTML] Als3 is a Candida albicans invasin that binds to cadherins and induces endocytosis by host cells

QT Phan, CL Myers, Y Fu, DC Sheppard… - PLoS …, 2007 - journals.plos.org
Candida albicans is the most common cause of hematogenously disseminated and oropharyngeal
candidiasis. Both of these diseases are characterized by fungal invasion of host cells. …

Evaluation and design of genome-wide CRISPR/SpCas9 knockout screens

…, M Rahman, M Costanzo, CL Myers… - G3: Genes …, 2017 - academic.oup.com
The adaptation of CRISPR/SpCas9 technology to mammalian cell lines is transforming the
study of human functional genomics. Pooled libraries of CRISPR guide RNAs (gRNAs) …

Systematic exploration of essential yeast gene function with temperature-sensitive mutants

…, G Giaever, C Nislow, C Bulawa, CL Myers… - Nature …, 2011 - nature.com
Conditional temperature-sensitive (ts) mutations are valuable reagents for studying essential
genes in the yeast Saccharomyces cerevisiae. We constructed 787 ts strains, covering 497 (…

Quantitative analysis of fitness and genetic interactions in yeast on a genome scale

…, GW Brown, B Andrews, C Boone, CL Myers - Nature …, 2010 - nature.com
Global quantitative analysis of genetic interactions is a powerful approach for deciphering
the roles of genes and mapping functional relationships among pathways. Using colony size …

[HTML][HTML] Comprehensive curation and analysis of global interaction networks in Saccharomyces cerevisiae

…, L Boucher, BJ Breitkreutz, GC Hon, CL Myers… - Journal of biology, 2006 - Springer
Background The study of complex biological networks and prediction of gene function has
been enabled by high-throughput (HTP) methods for detection of genetic and protein …

Systematic exploration of synergistic drug pairs

…, G Giaever, C Nislow, CL Myers… - Molecular systems …, 2011 - embopress.org
Drug synergy allows a therapeutic effect to be achieved with lower doses of component
drugs. Drug synergy can result when drugs target the products of genes that act in parallel …

Exploring the functional landscape of gene expression: directed search of large microarray compendia

MA Hibbs, DC Hess, CL Myers, C Huttenhower… - …, 2007 - academic.oup.com
Motivation: The increasing availability of gene expression microarray technology has
resulted in the publication of thousands of microarray gene expression datasets investigating …

[HTML][HTML] A critical assessment of Mus musculusgene function prediction using integrated genomic evidence

L Peña-Castillo, M Tasan, CL Myers, H Lee, T Joshi… - Genome biology, 2008 - Springer
Background: Several years after sequencing the human genome and the mouse genome,
much remains to be discovered about the functions of most human and mouse genes. …