Noxious skin stimuli which are sufficiently intense to produce tissue injury, characteristically
generate prolonged post-stimulus sensory disturbances that include continuing pain, an …

We describe those sensations that are unpleasant, intense, or distressing as painful. Pain is
not homogeneous, however, and comprises three categories: physiological, inflammatory, …

Nociceptor inputs can trigger a prolonged but reversible increase in the excitability and
synaptic efficacy of neurons in central nociceptive pathways, the phenomenon of central …

Acute postoperative pain is followed by persistent pain in 10–50% of individuals after common
operations, such as groin hernia repair, breast and thoracic surgery, leg amputation, and …

Central sensitization represents an enhancement in the function of neurons and circuits in
nociceptive pathways caused by increases in membrane excitability and synaptic efficacy as …

We highlight current theories about peripheral neuropathic pain and show that progress in
management is contingent on targeting treatment not at the aetiological factors or the …

… Swett JE, Woolf CI. Somatotopic organization of primary afferent terminals in the superficial
… Woolf CJ, Wall PD. Chronic peripheral nerve section diminishes the primary afferent A-fibre …

… Address correspondence and reprint requests to Professor CJ Woolf, Department of
Anatomy and Developmental Biology, University College and Middlesex School of Medicine …

… JG and Robinson, CJ. Peripheral neural correlates of magnitude of cutaneous pain and
hyperalgesia: … 37 Woolf, CJ. Long term alterations in the excitability of the flexion reflex produced …

Neuropathic pain is triggered by lesions to the somatosensory nervous system that alter its
structure and function so that pain occurs spontaneously and responses to noxious and …