Voluntary movement is a fundamental way in which animals respond to, and interact with,
their environment. In mammals, the main CNS pathway controlling voluntary movement is the …

Huntington disease is one of nine inherited neurodegenerative disorders caused by a
polyglutamine tract expansion. Expanded polyglutamine proteins accumulate abnormally in …

The physical continuity of axons over long cellular distances poses challenges for their
maintenance. One organelle that faces this challenge is endoplasmic reticulum (ER); unlike other …

We have developed an approach for the in situ detection of genomic elements that regulate
transcription zin Drosophila melanogaster. The approach is analogous to a powerful method …

Tetanus toxin cleaves the synaptic vesicle protein synaptobrevin, and the ensuing loss of
neurotransmitter exocytosis has implicated synaptobrevin in this process. To further the study …

Parkinson’s disease (PD) is characterized pathologically by intraneuronal inclusions called
Lewy bodies, largely comprised of α-synuclein. Multiplication of the α-synuclein gene locus …

Autophagy is a major clearance route for intracellular aggregate-prone proteins causing
diseases such as Huntington's disease. Autophagy induction with the mTOR inhibitor rapamycin …

mTOR (mammalian target of rapamycin) signalling and macroautophagy (henceforth
autophagy) regulate numerous pathological and physiological processes, including cellular …

Many neurodegenerative diseases are caused by intracellular, aggregate-prone proteins,
including polyglutamine-expanded huntingtin in Huntington's disease (HD) and mutant tau in …

… as transformants in a previous experiment (O'Kane and Gehring 1987). Some of these P[lac,Ty*]A
strains have already been described (Ghysen and O'Kane 1989). The last digit of each …