Predictors of mortality in hospitalized COVID‐19 patients: a systematic review and meta‐analysis
Mortality rates of coronavirus disease‐2019 (COVID‐19) continue to rise across the world.
Information regarding the predictors of mortality in patients with COVID‐19 remains scarce. …
Information regarding the predictors of mortality in patients with COVID‐19 remains scarce. …
Mechanisms of vascular smooth muscle contraction and the basis for pharmacologic treatment of smooth muscle disorders
FV Brozovich, CJ Nicholson, CV Degen, YZ Gao… - Pharmacological …, 2016 - ASPET
The smooth muscle cell directly drives the contraction of the vascular wall and hence
regulates the size of the blood vessel lumen. We review here the current understanding of the …
regulates the size of the blood vessel lumen. We review here the current understanding of the …
[HTML][HTML] Estimating risk of mechanical ventilation and in-hospital mortality among adult COVID-19 patients admitted to Mass General Brigham: The VICE and DICE …
CJ Nicholson, L Wooster, HH Sigurslid, RH Li… - …, 2021 - thelancet.com
Background Risk stratification of COVID-19 patients upon hospital admission is key for their
successful treatment and efficient utilization of hospital resources. We sought to evaluate the …
successful treatment and efficient utilization of hospital resources. We sought to evaluate the …
HDAC9 is implicated in atherosclerotic aortic calcification and affects vascular smooth muscle cell phenotype
…, SJ Hwang, J Wang, L Lu, CJ Nicholson… - Nature …, 2019 - nature.com
Aortic calcification is an important independent predictor of future cardiovascular events. We
performed a genome-wide association meta-analysis to determine SNPs associated with …
performed a genome-wide association meta-analysis to determine SNPs associated with …
Characterization of the adverse effects of nicotine on placental development: in vivo and in vitro studies
…, S Raha, F Sergent, CJ Nicholson… - American Journal …, 2014 - journals.physiology.org
In utero exposure to nicotine is associated with increased risk of numerous adverse fetal and
neonatal outcomes, which suggests that it acts directly to affect placental development and …
neonatal outcomes, which suggests that it acts directly to affect placental development and …
Implementing advance care planning with community-dwelling frail elders requires a system-wide approach: an integrative review applying a behaviour change …
Background: Facilitating advance care planning with community-dwelling frail elders can be
challenging. Notably, frail elders’ vulnerability to sudden deterioration leads to uncertainty in …
challenging. Notably, frail elders’ vulnerability to sudden deterioration leads to uncertainty in …
The importance of living well now and relationships: a qualitative study of the barriers and enablers to engaging frail elders with advance care planning
Background: The population of frail elders is growing, and due to their vulnerability to sudden
deterioration, advance care planning is particularly important. However, advance care …
deterioration, advance care planning is particularly important. However, advance care …
[HTML][HTML] Estrogenic vascular effects are diminished by chronological aging
CJ Nicholson, M Sweeney, SC Robson, MJ Taggart - Scientific reports, 2017 - nature.com
The beneficial role of estrogen in the vascular system may be due, in part, through reduction
of peripheral vascular resistance. The use of estrogen therapy to prevent cardiovascular …
of peripheral vascular resistance. The use of estrogen therapy to prevent cardiovascular …
Polymorphisms in the ACE2 Locus Associate with Severity of COVID-19 Infection
L Wooster, CJ Nicholson, HH Sigurslid… - MedRxiv, 2020 - medrxiv.org
Data from clinical studies suggests a strong association between underlying cardiometabolic
disease and worse outcomes in COVID-19. Given that the SARS-CoV-2 virus has a unique …
disease and worse outcomes in COVID-19. Given that the SARS-CoV-2 virus has a unique …
[HTML][HTML] Estimating risk of mechanical ventilation and mortality among adult COVID-19 patients admitted to Mass General Brigham: the VICE and DICE scores
CJ Nicholson, L Wooster, HH Sigurslid, RF Li, W Jiang… - Medrxiv, 2020 - ncbi.nlm.nih.gov
Background: Risk stratification of COVID-19 patients upon hospital admission is key for their
successful treatment and efficient utilization of hospital resources. Objective: To evaluate the …
successful treatment and efficient utilization of hospital resources. Objective: To evaluate the …