The fibronectin (FN) gene has become paradigmatic to illustrate genome evolution by exon
shuffling, generation of protein diversity by alternative mRNA splicing, and topological …

It has been assumed that constitutive and regulated splicing of RNA polymerase II transcripts
depends exclusively on signals present in the RNA molecule. Here we show that changes …

Haploid Saccharomyces cerevisiae yeast cells use a prototypic cell signalling system to
transmit information about the extracellular concentration of mating pheromone secreted by …

Organismal fitness depends on the ability of gene networks to function robustly in the face of
environmental and genetic perturbations. Understanding the mechanisms of this stability is …

The yeast two-hybrid (Y2H) system exploits host cell genetics in order to display binary
protein–protein interactions (PPIs) via defined and selectable phenotypes. Numerous …

Splitting and apparent splicing of ribosomal RNA, both previously unknown in vertebrates,
were found in rodents of the genus Ctenomys. Instead of being formed by a single molecule of …

D-xylonate is a potential platform chemical which can be produced by engineered
Saccharomyces cerevisiae strains. In order to address production constraints in more detail, we …

One goal of systems biology is to understand how genome-encoded parts interact to produce
quantitative phenotypes. The Alpha Project is a medium-scale, interdisciplinary systems …

We have previously proposed a molecular interaction between the liver factors that bind to
the cyclic AMP response element (CRE) and CCAAT sites of the fibronectin (FN) gene based …

It is well known that uninfected mammalian cells contain DNA sequences which are closely
related to retroviral genomic segments. However, these sequences seldom (if ever) have …