User profiles for C. G. Knight

Chris Knight

University of Manchester
Verified email at manchester.ac.uk
Cited by 2809

Harnessing rhizosphere microbiomes for drought-resilient crop production

FT de Vries, RI Griffiths, CG Knight, O Nicolitch… - Science, 2020 - science.org
Root-associated microbes can improve plant growth, and they offer the potential to increase
crop resilience to future drought. Although our understanding of the complex feedbacks …

L-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H and L

…, MA Brown, H Kirschke, CG Knight… - Biochemical …, 1982 - portlandpress.com
1. L-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) at a concentration of 0.5
mM had no effect on the serine proteinases plasma kallikrein and leucocyte elastase or the …

[HTML][HTML] Structural basis of collagen recognition by integrin α2β1

J Emsley, CG Knight, RW Farndale, MJ Barnes… - Cell, 2000 - cell.com
We have determined the crystal structure of a complex between the I domain of integrin α2β1
and a triple helical collagen peptide containing a critical GFOGER motif. Three loops on the …

[HTML][HTML] The Collagen-binding A-domains of Integrins α1β1 and α2β1recognize the same specific amino acid sequence, GFOGER, in native (Triple-helical) collagens

CG Knight, LF Morton, AR Peachey… - Journal of Biological …, 2000 - ASBMB
We have previously assigned an integrin α 2 β 1 -recognition site in collagen I to the
sequence, GFOGERGVEGPOGPA (O = Hyp), corresponding to residues 502–516 of the α 1 (I) …

A novel coumarin-labelled peptide for sensitive continuous assays of the matrix metalloproteinases

CG Knight, F Willenbrock, G Murphy - FEBS letters, 1992 - Elsevier
(7-methoxycoumarin-4-yl)Acetyl-Pro-Leu-Gly-Leu-(3-[2,4-dinitrophenyl]-l-2,3-diaminopropionyl)-Ala-Arg-NH
2 (Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH 2 ) has been synthesised as a …

[HTML][HTML] TNF-α converting enzyme (TACE) is inhibited by TIMP-3

…, PM Slocombe, A Webster, M Butler, CG Knight… - FEBS letters, 1998 - Elsevier
TNF-α converting enzyme (TACE; ADAM-17) is a membrane-bound disintegrin
metalloproteinase that processes the membrane-associated cytokine proTNF-α to a soluble form. …

Xanthene-dye-labelled phosphatidylethanolamines as probes of interfacial pH. Studies in phospholipid vesicles

CG Knight, T Stephens - Biochemical Journal, 1989 - portlandpress.com
We have been developing the use of plasma-membrane-bound fluorescent probes to measure
the pH values at the surfaces of living chondrocytes. For this purpose, three lipophilic pH …

The collagen-platelet interaction

MJ Barnes, CG Knight… - Current opinion in …, 1998 - journals.lww.com
Collagen-platelet interaction, occurring in hemostasis but also a cause of thrombosis, is a
two-step process of adhesion and activation involving the sequential recognition of distinct …

[HTML][HTML] The in vitro activity of ADAM-10 is inhibited by TIMP-1 and TIMP-3

A Amour, CG Knight, A Webster, PM Slocombe… - FEBS letters, 2000 - Elsevier
A recombinant soluble form of the catalytic domain of human ADAM-10 was expressed as
an Fc fusion protein from myeloma cells. The ADAM-10 was catalytically active, cleaving …

[HTML][HTML] Genomic and genetic analyses of diversity and plant interactions of Pseudomonas fluorescens

…, CD Moon, SM Gehrig, SAC Godfrey, CG Knight… - Genome biology, 2009 - Springer
Background Pseudomonas fluorescens are common soil bacteria that can improve plant
health through nutrient cycling, pathogen antagonism and induction of plant defenses. The …