Following the discovery of NVP-BEZ235, our first dual pan-PI3K/mTOR clinical compound,
we sought to identify additional phosphoinositide 3-kinase (PI3K) inhibitors from different …

Phosphoinositide-3-kinases (PI3Ks) are important oncology targets due to the deregulation
of this signaling pathway in a wide variety of human cancers. Herein we describe the …

Therapeutic options for the treatment of an increasing variety of cancers have been expanded
by the introduction of a new class of drugs, commonly referred to as checkpoint blocking …

We report an investigation of the structure, evolutionary history, and function of the highly
repeated DNA family named Long Interspersed Sequence One (L1). Hybridization studies show…

We have characterized a large repetitive element which has been found at seven different
locations within the beta globin locus of the BALB/c mouse. This repeat has an unusual …

Here we describe a post-translational modification of SC-63032, a variant of the species
restricted, multi-lineage hematopoeitic factor human interleukin-3 (hIL-3). We have made two …

Clones containing five non-adult/3-globin genes were isolated from a library of BALB/c DNA.
Together, the newly cloned regions comprise a contiguous block of 32 kb of the mouse …

The nucleotide sequence of 55,856 base-pairs containing all seven β-globin homologous
structures from chromosome 7 of the BALB/c mouse is reported. This sequence links together …

We have determined the complete nucleotide sequence for five members of the L1Md
repetitive family from the beta-globin gene region of the BALB/c mouse. The five repeats are …

… of which is missing from most copies (Fanning 1983; Voliva et al. 1983; for review, see
Rogers … D4G and D2G correspond to Ll Md4 and LlMd-2 of Voliva et al. (1984). Thick lines are …