Ultra-high-throughput sequencing is emerging as an attractive alternative to microarrays for
genotyping, analysis of methylation patterns, and identification of transcription factor binding …

Methylation of the N 6 position of adenosine (m 6 A) is a posttranscriptional modification of
RNA with poorly understood prevalence and physiological relevance. The recent discovery …

Structural variants are implicated in numerous diseases and make up the majority of varying
nucleotides among human genomes. Here we describe an integrated set of eight structural …

DNA methylation is a chemical modification of cytosine bases that is pivotal for gene
regulation,cellular specification and cancer development. Here, we describe an R package, …

We have undertaken a genome-wide analysis of rare copy-number variation (CNV) in 1124
autism spectrum disorder (ASD) families, each comprised of a single proband, unaffected …

N 6 -methyladenosine (m6A) is the most abundant modified base in eukaryotic mRNA and
has been linked to diverse effects on mRNA fate. Current mapping approaches localize m6A …

INTRODUCTION To date, 559 humans have been flown into space, but long-duration (>300
days) missions are rare (n = 8 total). Long-duration missions that will take humans to Mars …

N 6 -methyladenosine (m 6 A) is an abundant nucleotide modification in mRNA that is
required for the differentiation of mouse embryonic stem cells. However, it remains unknown …

A large number of computational methods have been developed for analyzing differential
gene expression in RNA-seq data. We describe a comprehensive evaluation of common …

Aging is characterized by clonal expansion of myeloid-biased hematopoietic stem cells and
by increased risk of myeloid malignancies. Exome sequencing of three elderly females with …